Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A map of the interactome network of the metazoan C. elegans.
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.
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TIR-1 identified as central regulator of innate immunity
"tir-1, which encodes an ortholog of SARM, a Toll-interleukin 1 receptor (TIR) domain protein"
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TIR-1 controls expression of antimicrobial peptides NLP-29 and NLP-31
"Expression of two of these peptides, NLP-29 and NLP-31, was differentially regulated by fungal and bacterial infection and was controlled in part by tir-1"
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TIR-1 functions independently of Toll-like receptor TOL-1
"the activity of tir-1 was independent of the single nematode Toll-like receptor"
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TIR-1 interacts with RAB-1 small GTPase and ATP synthase
"We identify protein partners for TIR-1 and show that the small GTPase Rab1 and the f subunit of ATP synthase participate specifically in the control of antimicrobial peptide gene expression"
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TIR-1 RNAi causes increased susceptibility to infection
"Inactivation of tir-1 by RNA interference caused increased susceptibility to infection"
A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.
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TIR-1 (nsy-2) specifies AWC neuron asymmetry
"encodes a conserved post-synaptic protein that specifies the choice between AWC(OFF) and AWC(ON)"
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Acts downstream of CaMKII (UNC-43)
"Genetic evidence suggests that tir-1 acts downstream of a voltage-gated calcium channel and CaMKII (UNC-43) to regulate AWC asymmetry via the NSY-1(ASK1) p38/JNK MAP (mitogen-activated protein) kinase cascade"
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Localizes NSY-1 to postsynaptic regions via SAM domains
"TIR-1 localizes NSY-1 to post-synaptic regions of AWC, and TIR-1 binds UNC-43, suggesting that it assembles a synaptic signaling complex that regulates odorant receptor expression"
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Assembles signaling complex at synapses
"TIR-1 binds UNC-43, suggesting that it assembles a synaptic signaling complex that regulates odorant receptor expression"
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TIR domain activates signaling via SAM-mediated localization
"TIR-1 is a multidomain protein with a TIR (Toll-interleukin-1 receptor) domain that activates signaling, SAM repeats that mediate localization to post-synaptic regions of axons, and an N-terminal inhibitory domain"
Specificity and complexity of the Caenorhabditis elegans innate immune response.
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TIR-1 regulates distinct sets of antimicrobial genes
"different immune response pathways regulate expression of distinct but overlapping sets of antimicrobial genes"
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Complex patterns of gene regulation in response to different pathogens
"different bacterial pathogens regulate distinct but overlapping sets of antimicrobial genes"
Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade.
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TIR-1 integrates signals from biotic and abiotic stresses
"signals from both biotic and abiotic stresses are integrated by TIR-1, a TIR domain adaptor protein orthologous to human SARM, and a p38 MAP kinase signaling cassette"
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Required for pgp-5 transcription in response to infection
"the transcription of a Caenorhabditis elegans ABC transporter, pgp-5 is induced by both bacterial infection and heavy metal stress"
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Works through p38 MAPK cascade
"signals from both biotic and abiotic stresses are integrated by TIR-1, a TIR domain adaptor protein orthologous to human SARM, and a p38 MAP kinase signaling cassette"
Distinct innate immune responses to infection and wounding in the C. elegans epidermis.
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TIR-1 regulates nlp-29 expression in epidermis
"Infection of the nematode Caenorhabditis elegans by the natural fungal pathogen Drechmeria coniospora induces the expression in the epidermis of antimicrobial peptide (AMP) genes such as nlp-29"
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Required for response to fungal infection and wounding
"the C. elegans epidermis actively responds to wounding and infection via distinct pathways that converge on a conserved signaling cassette"
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Works through p38 MAPK cascade
"a conserved p38-MAP kinase cascade is required in the epidermis for the response to both infection and wounding"
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
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Independent confirmation of TIR-1 self-interaction
"Through a new empirical quality control framework, we show that the resulting data set (Worm Interactome 2007, or WI-2007) was similar in quality to low-throughput data curated from the literature"
Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans.
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SARM-ASK1-MKK3 module regulates innate immunity cell-autonomously
"Immunity in C. elegans requires a signaling module comprised of orthologs of the mammalian Toll-interleukin-1 receptor (TIR) domain protein SARM, the mitogen-activated protein kinase kinase kinase (MAPKKK) ASK1, and MAPKK MKK3, which activates p38 MAPK"
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Also regulates neuroendocrine responses including serotonin-dependent aversive behavior
"the cell-autonomous regulation of innate immunity and the neuroendocrine regulation of serotonin-dependent aversive behavior"
RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.
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TIR-1 regulates tph-1 expression in ADF neurons
"A subsequent study indicated that the TIR-domain adaptor protein TIR-1, which was initially identified as an upstream regulator of a conserved mitogen-activated protein kinase (MAPK) signaling pathway in the innate immunity"
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Works through DAF-19/ATF-7 transcription factors
"TIR-1 via a conserved mitogen-activated protein kinase (MAPK) signaling cascade induces innate immunity and upregulates serotonin (5-HT) biosynthesis gene tph-1"
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Common transcriptional effectors for immune and serotonergic responses
"Regulation of TIR-1 signaling in ADF neurons"
SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
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TIR-1 TIR domain dimerization leads to NAD+ loss
"Dimerization of the TIR domain from the Caenorhabditis elegans SARM1 ortholog TIR-1 leads to NAD+ loss and neuronal death"
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Evolutionarily conserved function in neuronal destruction
"indicating these activities are an evolutionarily conserved feature of SARM1 function"
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TIR domain contains SARM1-specific motifs required for NADase activity
"dimerization of the SARM1 TIR domain promotes consumption of the essential metabolite NAD+ and induces neuronal destruction"
NAD(+) cleavage activity by animal and plant TIR domains in cell death pathways.
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TIR-1 has NAD+ cleavage activity
"feature self-association-dependent NAD+ cleavage activity associated with cell death signaling"
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Self-association of TIR domains required for activity
"Both processes depend on closely related Toll/interleukin-1 receptor (TIR) domains in these proteins, which, as we show, feature self-association-dependent NAD+ cleavage activity associated with cell death signaling"
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Crystal structures reveal conserved substrate binding site
"The crystal structures of ribose and NADP+ (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and plant NLR RUN1 TIR domains, respectively, reveal a conserved substrate binding site"
A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration.
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Citrate induces phase transition enhancing SARM1/TIR-1 activity
"Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) is a neuronally expressed NAD+ glycohydrolase whose activity is increased in response to stress"
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TIR-1 multimerization essential for degeneration in vivo in C. elegans
"TIR-1/SARM1 multimerization is essential for degeneration in vivo"
Deep research report on tir-1