GO_REF:0000002

Gene Ontology annotation reference GO_REF:0000002

GO_REF:0000024

Gene Ontology annotation reference GO_REF:0000024

GO_REF:0000033

Gene Ontology annotation reference GO_REF:0000033

GO_REF:0000116

Gene Ontology annotation reference GO_REF:0000116

GO_REF:0000120

Gene Ontology annotation reference GO_REF:0000120

PMID:35177605

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

Human MRM2 is required for late mtLSU assembly independently of its methyltransferase activity.

"The catalytic activity of MRM2 is dispensable for mtLSU biogenesis"
Knockdown of fly CG11447/Mrm2 causes mitochondria-related developmental arrest.

"Disruption of the MRM2 Drosophila melanogaster orthologue leads to mitochondria-related developmental arrest."

file:DROME/Mrm2/Mrm2-uniprot.txt

Mrm2-uniprot.txt

file:DROME/Mrm2/Mrm2-bioinformatics/RESULTS-rereview.md

Mrm2 catalytic-site conservation check (re-review)

The RlmE catalytic lysine and the SAM-binding residues are conserved in Q9VDT6.

"maps to Q9VDT6 K201 (conserved)"

file:DROME/Mrm2/Mrm2-deep-research-falcon.md

Mrm2-deep-research-falcon.md