Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniPathway vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids.

Development of a high-density assay for long-chain fatty acyl-CoA elongases.

Defining the membrane proteome of NK cells.

The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy.

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.

The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.

Dominant ELOVL1 mutation causes neurological disorder with ichthyotic keratoderma, spasticity, hypomyelination and dysmorphic features.

De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.

The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation.

Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA

Linoleic acid (LA) metabolism

alpha-linolenic acid (ALA) metabolism

ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

Synthesis of very long-chain fatty acyl-CoAs