Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism.

The endoplasmic reticulum stress response in aging and age-related diseases.

Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking.

Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization.

S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome.

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.

Regulation of cholesterol biosynthesis by SREBP (SREBF)

S1P hydrolyzes SREBP1A,1C,2

ATF6 (ATF6-alpha) activates chaperones

Unfolded Protein Response (UPR)

MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)

MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)

ATF6B (ATF6-beta) activates chaperones

MBTPS1 (S1P) cleaves CREB3

MBTPS1 (S1P) cleaves CREB3L3

FAM20C phosphorylates FAM20C substrates

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.

Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.

Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene.

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress.

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.

UniProt entry Q14703 (MBTP1_HUMAN)