Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Subunit characterization of the Caenorhabditis elegans chaperonin containing TCP-1 and expression pattern of the gene encoding CCT-1.
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The C. elegans CCT complex was purified and shown to contain CCT-1 among at least seven subunit species, with a composition like bovine CCT.
"The chaperonin containing TCP-1 (CCT) from the free-living nematode Caenorhabditis elegans was purified and shown to contain at least seven subunit species ranging from 52-65 kDa"
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A cct-1 promoter reporter is expressed mainly in neuronal and muscle tissues, consistent with a role in actin and tubulin folding.
"Expression of a reporter gene under the control of the C. elegans cct-1 promoter is found to be mainly restricted to neuronal and muscle tissues"
Molecular analysis of Caenorhabditis elegans tcp-1, a gene encoding a chaperonin protein.
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The C. elegans TCP-1/CCT-1 protein is a 57-kDa subunit of a high-molecular-mass ATP-binding complex; tcp-1 is single-copy on chromosome II and constitutively expressed.
"Ce TCP-1 is a 57-kDa protein subunit of a high-molecular-mass complex capable of binding ATP"
Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans.
Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit.
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CCT/TRiC is an ATP-dependent folding machine for actin and tubulin.
"The eukaryotic cytosolic chaperonin CCT is an essential ATP-dependent protein folding machine whose action is required for folding the cytoskeletal proteins actin and tubulin"
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Purified yeast CCT catalyzes actin folding.
"Yeast CCT catalyses the folding of yeast ACT1p and human beta-actin with nearly identical rate constants and yields."
Physiological effects of unassembled chaperonin Cct subunits in the yeast Saccharomyces cerevisiae.
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CCT is built from eight distinct subunits Cct1p-Cct8p per ring that are functionally non-equivalent.
"stoichiometric array of eight different subunits, which are denoted Cct1p-Cct8p"
Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells.
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C. elegans CCT is required in vivo for microvillus formation in intestinal cells.
"is essential for proper formation of microvilli in intestinal cells"
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CCT depletion reduces tubulin levels and disorganizes the microtubule network.
"CCT depletion causes a reduction in the tubulin levels and disorganization of the microtubule network"
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CCT acts specifically on actin and tubulin among the filamentous cytoskeletons.
"suggesting substrate specificity of CCT in the folding of filamentous cytoskeletons in vivo"