DNAH7 notes

Identity and structure

UniProt Q8WXX0, 4024 aa, full dynein heavy chain architecture (stem 1..1289, AAA1-AAA6, stalk 2572..2873) [file:human/DNAH7/DNAH7-uniprot.txt].
Cryo-EM of human respiratory DMTs: "IDAb and IDAe are both DNAH7" PMID:37258679.
IDAb/IDAe motor domains modelled as copies of IDAg, "the other centrin-containing IDA" PMID:37258679.

Airway cilia, induced during ciliogenesis PMID:11877439.
Along entire respiratory axoneme; absent in CCDC39/CCDC40 ruler mutants PMID:39056782.
Reduced in sperm lacking radial spoke 1 (IQUB) PMID:39849482.

PMID:34476482
PMID:35543642; mitochondrial sheath defects.
PMID:40810911; ODA proteins unaffected.
The 2002 PCD case (PMID:11877439) lacked IDAs but DNAH7 was synthesised; the primary lesion was not shown to be in DNAH7.

Core MF: minus-end-directed microtubule motor activity (IBA; full motor domain). Core CC: inner dynein arm. Core BP: cilium movement; IDA assembly (structural subunit).
Calcium ion binding (InterPro EF-hand hit, no UniProt EF-hand): MARK_AS_OVER_ANNOTATED.
Dynein intermediate chain binding: UNDECIDED; PAINT IBD at PTN000743491 seeded only by dictyBase:DDB_G0276355 (cytoplasmic dynein) (interpro/panther/PTHR10676/PTHR10676-paint.tsv).
HPA sperm annulus: UNDECIDED (annulus is not axonemal).

Human DNAH7 (Q8WXX0) and mouse Dnah7a (E9Q0T8) / Dnah7c (A0A087WR13) receive the same 8 IBAs in QuickGO (incl. GO:0036156, GO:0036159, GO:0120316); no human/mouse family split as seen for DNAH12. DNAH7 itself seeds the PTN008503981 inner dynein arm IBD and PTN008951089 IDA assembly IBD.

Falcon deep research failed (Edison API authentication 503 errors on repeated attempts); review based on direct reading of cached literature.