PMID:26268547

Soybean transcription factor ORFeome associated with drought resistance: a valuable resource to accelerate research on abiotic stress resistance

C6T1A2 (Glyma17g18110.1) was cloned as part of a soybean transcription factor ORFeome associated with drought resistance (GenBank KT031152). The C2H2 zinc fingers are one of the seven largest transcription factor families in the collection.

PMID:24808098

The Arabidopsis ZINC FINGER PROTEIN3 Interferes with Abscisic Acid and Light Signaling in Seed Germination and Plant Development.

Arabidopsis ZFP3 is a nuclear C2H2 zinc-finger protein. Overexpression of ZFP3 and the related Arabidopsis ZFP1, ZFP4, ZFP6 and ZFP7 confers ABA insensitivity at germination.

UniProtKB:C6T1A2

UniProtKB entry C6T1A2 (C6T1A2_SOYBN), C2H2-Zn transcription factor, Glycine max.

210-aa unreviewed (TrEMBL) protein with a single C2H2-type zinc finger domain (residues 79-106), two disordered regions, and an N-terminal acidic compositional bias.
InterPro classifies the protein in IPR053266 (Zinc_finger_protein_7), IPR036236 (Znf_C2H2_sf) and IPR013087 (Znf_C2H2_type). PANTHER places it in PTHR47593:SF9 (C2H2-TYPE DOMAIN-CONTAINING PROTEIN) within PTHR47593 (ZINC FINGER PROTEIN 4-LIKE).
The only GO annotation in the UniProt DR lines is GO:0008270 (zinc ion binding, IEA:UniProtKB-KW). The GOA export has no rows.

file:SOYBN/C6T1A2/C6T1A2-bioinformatics/RESULTS-rereview.md

C6T1A2 re-review bioinformatics - motif positions, pairwise identities and PANTHER 19 tree placement.

The QALGGH motif is at residues 92-97 and a C-terminal LDLRL EAR-like match is at 206-210. C6T1A2 is identical to A0A2K7G974 (ZFP1).
C6T1A2 is in PTHR47593:SF9, a lineage produced by a Pentapetalae duplication (PTN002935045). The PTHR47593 tree has no Arabidopsis leaves and no PAINT nodes. The ZFP7/ZFP4 PAINT nodes are in the PTHR45730 tree.
Arabidopsis ZFP7, ZFP4, ZFP3 and ZFP2 are 34-37% identical overall to C6T1A2.

file:SOYBN/C6T1A2/C6T1A2-deep-research-falcon.md

Deep-research report (falcon / Edison Scientific Literature) - functional annotation of soybean C6T1A2 / Glyma17g18110.1 (C6T1A2).

No gene-specific experimental literature was identified for C6T1A2 / Glyma17g18110.1 from soybean.
Based on InterPro domain annotation, the protein is predicted to function as a DNA-binding transcription factor localized to the nucleus.

file:SOYBN/C6T1A2/C6T1A2-hypotheses/core-function-1-go-0003700/openscientist.md

OpenScientist hypothesis investigation - DNA-binding transcription factor activity

Reports the QALGGH motif at residues 92-97 and a C-terminal EAR-like motif, both reproduced independently in RESULTS-rereview.md. It also calls Arabidopsis ZFP7 the "direct ortholog" with 60.9% zinc-finger identity.

file:SOYBN/C6T1A2/C6T1A2-protnlm-predictions-review.yaml

ProtNLM2 prediction review for C6T1A2 - nucleus and ABA signaling predictions.

Prediction-review file for ProtNLM2 outputs (not consulted in the 2026-10-20 re-review).