Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.
Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes.
A human protein-protein interaction network: a resource for annotating the proteome.
Towards a proteome-scale map of the human protein-protein interaction network.
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy.
Nix is a selective autophagy receptor for mitochondrial clearance.
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy.
Nix, a receptor protein for mitophagy in mammals.
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
Network organization of the human autophagy system.
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
A directed protein interaction network for investigating intracellular signal transduction.
Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8.
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.
Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.
Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.
Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.
A proteome-scale map of the human interactome network.
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Regulation of endoplasmic reticulum turnover by selective autophagy.
Autophagy mediates degradation of nuclear lamina.
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.
Human CLEC16A regulates autophagy through modulating mTOR activity.
LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Regulation of autophagosome biogenesis by OFD1-mediated selective autophagy.
Cytoplasmic short linear motifs in ACE2 and integrin β(3) link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy.
Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.
Global Proximity Interactome of the Human Macroautophagy Pathway.
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy.
CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
ER-phagy restrains inflammatory responses through its receptor UBAC2.
p62 links damaged mitochondria to LC3
LC3 binds the autophagosome membrane Atg5-Atg12 complex
ATG16L1 complex transfers LC3 from ATG3 to PE
LC3 de-lipidation by ATG4
TBC1D25 (OATL1) binds ATG8 homologues
LC3 binds the autophagosome membrane Atg5-Atg12 complex
Phosphorylated FUNDC1 links damaged mitochondria to LC3
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
Enhanced autophagosome formation
SARS-CoV-2 M protein binds MAP1LC3B
RBX1:CUL3 dissociates from forming autophagosome
MAP1LC3B binds KEAP1 and SQSTM1
MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria
Exosomal secretion of DENV RNA and proteins
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis.
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.
UniProtKB entry Q9GZQ8 (MAP1LC3B)