Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Assertion of Orthology
Combined Automated Annotation using Multiple IEA Methods
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Structure and assembly pathway of the ribosome quality control complex.
-
Listerin is the E3 ligase that poly-ubiquitinates 60S-housed nascent polypeptides during RQC, and its specificity for nascent chain-60S complexes depends on NEMF.
-
NEMF recruits and stabilizes Listerin's N-terminal domain on the 60S while Listerin's C-terminal RWD domain contacts the ribosome to position the RING ligase domain near the nascent polypeptide exit tunnel.
Ubiquitination of stalled ribosome triggers ribosome-associated quality control.
Ribosome-associated quality-control mechanisms from bacteria to humans.
Reactome: rescue of stalled ribosome (LTN1)
Reactome: LTN1 cytosol localization
Reactome: LTN1 ubiquitin ligase activity
Reactome: LTN1 cytosol localization
UniProt entry O94822 (LTN1_HUMAN), E3 ubiquitin-protein ligase listerin
-
E3 ubiquitin-protein ligase component of the RQC complex (LTN1, TCF25, NEMF) on the 60S subunit; recruited to stalled 60S by NEMF and ubiquitinates stalled nascent chains for proteasomal extraction/degradation via VCP/p97; RING-type ligase, EC 2.3.2.27; cytosolic.