No deep-research provider was available; notes compiled from the UniProt entry and cached abstracts.
| PTN node | node term | n_seeds | leaf IBAs | seed annotation (term, evidence, PMID) | other seeds | IBD stands without this seed? | verdict | rationale |
|---|---|---|---|---|---|---|---|---|
| PTN000156046 | GO:0004655 porphobilinogen synthase activity | 9 | 149 (126 taxa) | GO:0004655, IMP, PMID:9529530 (PseudoCAP; also UniProt EXP PMID:16819823) | E. coli HemB P0ACB2, human ALAD P13716, bovine Q58DK5, mouse, rat, yeast HEM2, fly, Plasmodium Q8IL68 | Yes | SOUND | Activity directly measured after overexpression; complementation agrees. IDA would fit as well as IMP. Node term suits the ALAD family. |
No source defects. Metal ion binding MODIFY to magnesium ion binding. Actions: 9 ACCEPT, 1 MODIFY.