betT (E. coli K-12, P0ABC9) notes

Sources read (2026-11-03)

• Cached abstracts: PMID:1956285, PMID:17322201 (fetched), PMID:3512526, PMID:15919996, PMID:11967071.
• Deep research: falcon failed (403); just deep-research-openscientist ECOLI P0ABC9 --alias betT produced betT-deep-research-openscientist.md, consistent with the review (proton-driven, high-affinity, osmo-activated choline carrier); cited on the MF row.

Findings

• "betT encoding a proton-motive-force-driven, high-affinity transport system for choline" PMID:1956285
• 12 TM segments, cytoplasmic termini; osmotic upshock raises activity tenfold; the C-terminal domain is needed for activation PMID:17322201.

Decisions

• Core: GO:0015220 choline transmembrane transporter activity, GO:0015871 choline transport, plasma membrane.
• BCCT-family generic rows (GO:0022857, GO:0055085, GO:0016020) are MODIFIED to the specific terms. GO:0055085 -> GO:0015871 is lateral, because GO has no choline transmembrane transport term.
• The DNA damage response IEP (mitomycin microarray) is over-annotated.
• PANTHER PTHR30047:SF7 is not choline-specific (it also holds BetP, OpuD, BetL, EctP, TmaT), so neither the family nor that subfamily can define a choline-uptake selector.