GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10559471
Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins.
PMID:12134158
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.
PMID:12176041
DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.
PMID:15723800
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
PMID:19946888
Defining the membrane proteome of NK cells.
PMID:20458337
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
PMID:25416956
A proteome-scale map of the human interactome network.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32651375
Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Reactome:R-HSA-200952
Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction
Reactome:R-HSA-6798749
Exocytosis of specific granule lumen proteins
Reactome:R-HSA-9012999
RHO GTPase cycle
Reactome:R-HSA-9014296
RAC2 GEFs activate RAC2
Reactome:R-HSA-9014449
RHOG binds effectors at the plasma membrane
PMID:21613211
Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
PMID:26083206
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
PMID:12393632
DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.
PMID:12871644
DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells.
PMID:21892172
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
PMID:22905357
Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines.
PMID:16464467
An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).
PMID:17670792
A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.
PMID:15728191
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.
PMID:23650620
Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors.
UniProtKB:O15162
Phospholipid scramblase 1
UniProtKB:O76011
Keratin, type I cuticular Ha4
UniProtKB:P22735
Protein-glutamine gamma-glutamyltransferase K
UniProtKB:P36406
E3 ubiquitin-protein ligase TRIM23
UniProtKB:P49639
Homeobox protein Hox-A1
UniProtKB:Q15323
Keratin, type I cuticular Ha1
UniProtKB:Q5JR59
Microtubule-associated tumor suppressor candidate 2
UniProtKB:Q6A162
Keratin, type I cytoskeletal 40
UniProtKB:Q92824
Proprotein convertase subtilisin/kexin type 5
UniProtKB:Q9BWT7
Caspase recruitment domain-containing protein 10
UniProtKB:P15153
Ras-related C3 botulinum toxin substrate 2