Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
Automatic Gene Ontology annotation based on Rhea mapping
Protein AMPylation by an Evolutionarily Conserved Pseudokinase.
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SELO is a highly conserved pseudokinase that transfers AMP from ATP to Ser, Thr and Tyr residues of protein substrates (AMPylation), localises to mitochondria, AMPylates proteins involved in redox homeostasis, and is required for the proper cellular response to oxidative stress.
"SelO pseudokinases localize"
A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism.
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Mammalian SELO is a mitochondrial AMPylase that regulates metabolic flux by AMPylating key mitochondrial proteins (glutamate dehydrogenase, pyruvate dehydrogenase); SELO is conserved in E. coli and S. cerevisiae, where it AMPylates to protect cells from oxidative damage and cell death.
"SelO is conserved in E. coli and S. cerevisiae, where it catalyzes AMPylation to protect cells from oxidative damage and cell death"
Education and research: where are we going?
Protein adenylyltransferase SelO, mitochondrial (SELO_SCHPO)
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UniProt classifies O13890 in the SELO family with an N-terminal mitochondrial transit peptide, an ATP-binding site and a Mg(2+)-dependent catalytic centre; function is inferred from homology (PE 3).
"Pfam; PF02696; SelO; 1."