erg8 notes

2026-10-17 fungal PAINT/IBA re-review

• Target: S. pombe erg8 / SPAC343.01c / UniProt Q9UT88.
• Family context: PTHR31814:SF2, fungal GHMP phosphomevalonate kinase. The accepted PAINT node
  PTN001274235 carries phosphomevalonate kinase activity and the IPP mevalonate-pathway process;
  PTN001274236 carries the fungal ergosterol-biosynthesis process.
• The peroxisome IBA comes from PTN000781523. The PTHR31814 family review marks that node
  NEEDS_PRUNING; I retained REMOVE on S. pombe erg8 and changed the propagation source from the
  Arabidopsis seed to PANTHER:PTN000781523.
• The only cached PMID for this review is Matsuyama et al. 2006 PMID:16823372, and it is abstract-only.
  Therefore the high-throughput cytoplasm/cytosol calls are accepted, nucleus is kept as non-core,
  and mitochondrion is left UNDECIDED rather than removed.
• A fresh web search for newer direct S. pombe erg8 / SPAC343.01c / Q9UT88 functional papers did not
  find a newer gene-specific biochemical or localization paper.