Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11027560

Molecular cloning of a human, hemicholinium-3-sensitive choline transporter.

Direct human spinal-cord clone expressed in COS-7 cells; uptake kinetics and sodium/chloride dependence. Abstract recovered, with independent human uptake corroboration.

PMID:11068039

Functional characterization of the human high-affinity choline transporter.

Direct human clone in Xenopus oocytes; uptake and ion-dependence, not a native neuronal stoichiometric measurement.

PMID:12237312

Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate.

PMID:12969261

The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles.

Tagged CHT trafficking and rat-brain synaptic-vesicle isolation; native fractionation is rat, not human. Abstract-only canonical cache.

PMID:15953352

Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif.

Transporter internalization motif, Rab5 endosomes and increased surface uptake after endocytosis disruption; abstract-only canonical cache.

PMID:17005849

Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles.

Human hCHT in Xenopus oocytes, including trafficking mutant L530A/V531A. Full source recovered separately as a normal PMC URL; variable charge/uptake and regulatory-chloride interpretation are distinguished from measured ion requirements.

PMID:23132865

Transmembrane topology and oligomeric structure of the high-affinity choline transporter.

PMID:23141292

Defective presynaptic choline transport underlies hereditary motor neuropathy.

PMID:27569547

Impaired Presynaptic High-Affinity Choline Transporter Causes a Congenital Myasthenic Syndrome with Episodic Apnea.

Full primary source: human congenital myasthenic cases, native muscle junctional immunostaining and human variant uptake in HEK293T cells.

PMID:40972734

Diversity of human choline transporters: substrate specificity, kinetic properties, and inhibitor sensitivity.

2025 comparison of overexpressed human choline transporters. SLC5A7 uptake is direct; comparative kinetic values are assay-specific.

Reactome:R-HSA-264642

Acetylcholine Neurotransmitter Release Cycle

Reactome:R-HSA-429594

SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol

Reactome:R-HSA-5658483

Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol

Reactome:R-HSA-9958517

SLC-mediated bile acid transport

file:human/SLC5A7/SLC5A7-uniprot.txt

Curated UniProt record for human SLC5A7

PMID:11904763

Localisation of the high-affinity choline transporter-1 in the rat skeletal motor unit.

PMID:39657660

Ion coupling and inhibitory mechanisms of the human presynaptic high-affinity choline transporter CHT1.

Human CHT1 structural study; abstract supports ligand/ion recognition, with two sodium sites and chloride interacting with choline. Structural ion occupancy is not a measured transport stoichiometry.