Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.
Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements.
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways.
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.
A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53.
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex.
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt.
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
Binding of manumycin A inhibits IkappaB kinase beta activity.
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
Theileria-induced constitutive IKK activation is independent of functional Hsp90.
Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7.
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK.
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
A role for IkappaB kinase 2 in bipolar spindle assembly.
The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity.
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14.
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.
The IkappaB kinase complex: master regulator of NF-kappaB signaling.
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein.
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors.
Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling.
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
Expanding the substantial interactome of NEMO using protein microarrays.
An atlas of combinatorial transcriptional regulation in mouse and man.
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.
Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.
IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7.
Crystal structure of inhibitor of κB kinase β.
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers.
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.
Viral immune modulators perturb the human molecular network by common and unique strategies.
The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.
TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling.
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
IκB kinase phosphorylation of SNAP-23 controls platelet secretion.
SASH1 is a scaffold molecule in endothelial TLR4 signaling.
A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.
Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis.
Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex.
Architecture of the human interactome defines protein communities and disease networks.
Gain-of-function IKBKB mutation causes human combined immune deficiency.
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
WNT2B activates macrophages via NF-κB signaling pathway in inflammatory bowel disease.
Multimodal cell maps as a foundation for structural and functional genomics.
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells.
IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.
Activated IKK phosphorylates I-kappaB
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Active IKK Complex phosphorylates NF-kappa-B inhibitor
Toll Like Receptor 3 (TLR3) Cascade
Activated TAK1 mediates phosphorylation of the IKK Complex
RIP1 facilitates IKK complex phosphorylation
IKKbeta phosphorylates IkB causing NF-kB to dissociate
Activation of IKK complex
Ubiquitination of NEMO by TRAF6
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
IKBA is phosphorylated by Phospho IKKB kinase
Fc epsilon receptor (FCERI) signaling
Phosphorylation of IKK-beta by TAK1
NEMO binds polyubiquitinated IRAK1
NFKBIA variant is not phosphorylated within IkBA:NF-kappaB
Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG
Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
CHUK, IKBKB phosphorylate CYLD at S418
Regulation of TNFR1 signaling
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
CHUK, IKBKB and IKBKG form IKK complex
C-type lectin receptors (CLRs)
RACK1 binds IKKA:IKKB:NEMO
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
IKKB phosphorylates SNAP23
IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
Activation of IKK by MEKK1
Recruitment of IKK complex
IKBKG subunit of IKK complex binds polyubiquinated RIP1
NEMO subunit of IKK complex binds to activated IRAK1
TRIF (TICAM1)-mediated TLR4 signaling
NLRX1 binds CHUK:IKBKB:IKBKG
IKBIP binds IKBKB and CHUK
LRRC14 binds IKBKB and CHUK
NLRC5 binds IKBKB and CHUK
TRAF2,6 ubiquitinates NLRC5
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9
SARS-CoV-2 9b binds IKBKG
Ubiquitination of IKBKG by TRAF6
MyD88 cascade initiated on plasma membrane
USP18 binds IKBKG within IKK complex
Active IKBKB phosphorylates NF-kappa-B inhibitor
CHUK, IKBKB phosphorylate RIPK1 at S25
IKK complex is activated by PKR
SLC15A4:TASL-dependent IRF5 activation
Activated IKBKB phosphorylates IRF5
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)
FKBP5 binds CHUK:IKBKB:IKBKG
UniProtKB record for human IKBKB