GO_REF:0000024

ISS - Inferred from Sequence or Structural Similarity

Sequence similarity to characterized C. elegans ortholog DHS-16 supports functional inference

GO_REF:0000033

Annotation inferences using phylogenetic trees

PANTHER phylogenetic analysis places drd-5 in subfamily PTHR43313:SF18 (Short-chain dehydrogenase/reductase)
IBA annotations transferred from characterized orthologs including WB:WBGene00000979 (dhs-16)

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

DOI:10.1038/nchembio.2356

Small-molecule pheromones and hormones controlling nematode development

DHS-16 is a characterized SDR involved in dafachronic acid biosynthesis in C. elegans

DOI:10.3389/fevo.2021.735924

Hormonal regulation of diapause and development in nematodes, insects, and fishes

Reviews the role of dafachronic acid pathway enzymes including DHS-16 in nematode development

DOI:10.1002/prot.25666

The Short‐chain Dehydrogenase/Reductase Engineering Database (SDRED): A classification and analysis system for a highly diverse enzyme family

DOI:10.3390/genes14010110

Gene structure evolution of the short-chain dehydrogenase/reductase (SDR) family

file:CAEBR/drd-5/drd-5-deep-research-falcon.md

Deep research on drd-5 gene function

Comprehensive analysis of SDR family membership and nematode SDR exemplars including DHS-16 and RML enzymes

CHEBI:78698

Dafachronic acids (ChEBI)

Steroid acids derived from sterols by oxidation with a cytochrome p450 that bind and activate the orphan nuclear receptor DAF-12 in Caenorhabditis elegans; characterized by 3-oxo group at C3 position