Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Asterless is a scaffold for the onset of centriole assembly.
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.
CEP152 is a genome maintenance protein disrupted in Seckel syndrome.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.
Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.
MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Molecular architecture of a cylindrical self-assembly at human centrosomes.
CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization.
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Cep152 interacts with Plk4 and is required for centriole duplication.
Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly.
Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis.
The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly.
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CEP152 organizes a CEP63–CEP57 inhibitory complex and recruits centrosomal APC/C. Ubiquitylation-associated removal from the centrosome regulates pericentrin recruitment and spindle assembly; obligatory proteolysis is not established.
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Persistent APC/C-resistant CEP152 delays spindle microtubule nucleation and increases mitotic errors in human cells.
Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.
Manual deep research synthesis for human CEP152
The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
Deuterosome-mediated centriole biogenesis.
CEP152 source and ontology evidence extracted from authentic records