Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
Differential function of the two nucleotide binding domains on cystic fibrosis transmembrane conductance regulator.
A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator.
A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression.
The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange.
The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins.
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ClC-3B chloride channel localizes to Golgi and interacts with CFTR-associated PDZ proteins
"ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins"
Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2.
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-).
Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator.
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions.
Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat.
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
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Hsp90 cochaperones modulate CFTR protein folding and ΔF508 can be rescued by reducing Aha1
"Cell-surface rescue of the most common disease variant that is restricted to the ER, DeltaF508, can be initiated by partial siRNA silencing of the Hsp90 cochaperone ATPase regulator Aha1"
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CFTR interactome reveals chaperone network controlling protein folding for ER exit
"Using proteomics to assess global cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein interactions (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding"
Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors.
BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex.
Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.
Mechanism of direct bicarbonate transport by the CFTR anion channel.
SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia.
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates.
CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium.
Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone.
SLC26A9 stimulates CFTR expression and function in human bronchial cell lines.
A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system.
Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.
The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation.
CFTR and TMEM16A are separate but functionally related Cl- channels.
Proteomic identification of calumenin as a G551D-CFTR associated protein.
Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.
CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.
G551D-CFTR needs more bound actin than wild-type CFTR to maintain its presence in plasma membranes.
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.
Investigating CFTR and KCa3.1 Protein/Protein Interactions.
The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.
ATPase activity of the cystic fibrosis transmembrane conductance regulator.
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First direct measurement of ATP hydrolysis rate by purified CFTR demonstrating intrinsic ATPase activity
"In this study, we report the first measurements of the rate of ATP hydrolysis by purified, reconstituted CFTR"
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G551D mutation causes defective ATP hydrolysis and channel gating, proving ATP utilization for channel activity
"Following reconstitution the mutant protein exhibited both defective ATP hydrolysis and channel gating, providing direct evidence that CFTR utilizes ATP to gate its channel activity"
Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator).
Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.
Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Electronic Gene Ontology annotations created by ARBA machine learning models
Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells.
The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.
Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Sec16A is critical for both conventional and unconventional secretion of CFTR.
Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages.
TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents.
Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary.
The ABCC family mediates organic anion transport
ABC-family proteins mediated transport
HCO3- transport through ion channel
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane
GOPC promotes translocation of CFTR to lysosomes
Defective CFTR does not transport Cl- from cytosol to extracellular region
CFTR transports Cl- from cytosol to extracellular region
Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region
Ivacaftor binds CFTR G551D
USP10 deubiquitinates SNX3, CFTR
AP-2 directly binds some endocytic cargo
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
RNF5 and RNF185 ubiquitinate misfolded CFTR
CFTR binds components of the ERAD machinery for ubiquitination and degradation
misfolded CFTR is degraded by the 26S proteasome
CFTR transits to the plasma membrane
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol
RNF5 and RNF185 ubiquitinate CFTR F508del
CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation
CFTR F508del is degraded by the 26S proteasome
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
Parkin transfers Ub to misfolded proteins
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
PolyUb-Misfolded proteins bind vimentin to form aggresome
Aggresome dissociates from dynein and microtubule
CFTR F508del binds CFTR correctors
Deep research on CFTR function