Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes.
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ADM2/Intermedin is a novel member of the calcitonin/CGRP peptide family
"Intermedin is a calcitonin/calcitonin gene-related peptide family peptide"
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Expressed primarily in pituitary and gastrointestinal tract
"intermedin is expressed primarily in the pituitary and gastrointestinal tract"
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Signals through CRLR/RAMP receptor complexes
"a CRLR/RAMP receptor complex is required for intermedin signaling"
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Increases cAMP production
"Intermedin increased cAMP production in SK-N-MC and L6 cells"
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Acts as a nonselective agonist for RAMP coreceptors
"intermedin represents a nonselective agonist for the RAMP coreceptors"
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Reduces blood pressure in normal and hypertensive rats
"intermedin treatment led to blood pressure reduction in both normal and spontaneously hypertensive rats"
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Suppresses gastric emptying and food intake
"in vivo treatment in mice with intermedin led to suppression of gastric emptying activity and food intake"
Intermedin is a new angiogenic growth factor.
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IMD promotes angiogenesis in ischemic hindlimb
"IMD gene delivery also increased capillary and arteriole density in ischemic hindlimb"
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Increases capillary and arteriole density
"increased capillary and arteriole density in ischemic hindlimb, identified by anti-CD-31 and alpha-smooth muscle actin immunostaining"
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Induces endothelial cell migration and tube formation
"In cultured endothelial cells, IMD induced cell migration and tube formation"
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Effects mediated via ERK, Akt/NOS/NO, and VEGF/VEGFR-2 pathways
"these effects were blocked by the inhibition of extracellular signal-regulated kinase (ERK), Akt, nitric oxide (NO) synthase (NOS), vascular endothelial growth factor receptor-2 (VEGFR-2)"
Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells.
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IMD exerts pro-angiogenic effects on HUVECs
"IMD exerted a significant in vitro angiogenic action"
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Mediated through CLR/RAMP1 and CLR/RAMP2 receptors
"Both CLR/RAMP1 and CLR/RAMP2 appeared to mediate the pro-angiogenic effect"
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Increases VEGF mRNA expression
"a significant increase of vascular endothelial growth factor (VEGF) mRNA expression 18 h following IMD administration"
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Induces VEGFR-2 phosphorylation
"a significant increase of VEGF receptor-2 phosphorylation as early as 5 min following IMD administration"
Structure and Dynamics of Adrenomedullin Receptors AM(1) and AM(2) Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
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Cryo-EM structure of AM2R in complex with intermedin/ADM2 at 2.3 angstrom
"structures of the AM2R in complex with either AM or intermedin/adrenomedullin 2 (AM2) and Gs at 2.4 and 2.3 Å, respectively"
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Reveals mechanisms of RAMP modulation of CLR phenotype
"Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins"
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Structural basis for ligand recognition
"The structures reveal distinctions in the primary orientation of the extracellular domains (ECDs) relative to the receptor core"
Liganded Gs-activating GPCR acts as a GEF for Gs
The adrenomedullin receptor can bind adrenomedullin and intermedin
The Ligand:GPCR:Gs complex dissociates
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
Deep research on ADM2 gene