AHP1 (YLR109W, P38013) notes

Module context: glutathione_thioredoxin_redox_systems, thiol_peroxidase_step, variant atypical_2cys_prx ("Atypical 2-Cys peroxiredoxin (AHP1)"), MF GO:0140824, BP GO:0042744, cytosol. Not in the YeastPathways summary; no RCA rows; no S. cerevisiae GO-CAM.

Evidence

• Prx5 subfamily, 176 aa, PANTHER PTHR10430:SF16 [UniProt:P38013].
• Thioredoxin-dependent peroxidase PMID:10391912.
• Substrate preference and electron donor PMID:9888818; PMID:9888818.
• Abundance: PMID:10681558; cTPx III = "TSA II/AHPC1".
• Metal/GSH-depletion sensitivity PMID:12270680.
• Cad1 signalling, urmylation, Mn homeostasis [UniProt:P38013].

Nomenclature caution

• "TSA II" in PMID:10681558 means AHP1, while "cTPx II" means TSA2. "Type II TPx" (PMID:9888818) is AHP1. This naming collision probably explains why TSA2 also carries SGD rows from PMID:9888818 (see TSA2 notes).
• The module labels AHP1 "atypical 2-Cys"; UniProt describes its catalytic cycle as intersubunit (typical-like) disulfide, Cys62 with Cys31 of the partner subunit per crystal structures. The "atypical" label in the module variant is questionable; "Prx5-type" would be safer.

Localisation

• Experimental: cytoplasm (PMID:10681558), cytosol (SWAT HDA). C-terminus AHL matches PTS1 consensus and Candida PMP20 is peroxisomal PMID:10391912, so IBA peroxisome kept non-core. IBA mitochondrion marked over-annotated (no presequence; PRX1 is the yeast mitochondrial Prx). Plasma membrane HDA marked over-annotated (abundant soluble protein in membrane proteome).

Decisions

• Obsolete GO:0008379 rows -> MODIFY GO:0140824. Bare protein binding (PXA2, MYTH) -> REMOVE. NOT protein stabilization accepted.