Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.
-
FAR1 reduces C16/C18 fatty acyl-CoA esters to fatty alcohols, requires NADPH, and localizes to the peroxisome.
"FAR1 preferred saturated"
Posttranslational regulation of fatty acyl-CoA reductase 1, Far1, controls ether glycerophospholipid synthesis.
PEX14 is required for microtubule-based peroxisome motility in human cells.
Topogenesis and homeostasis of fatty acyl-CoA reductase 1.
-
Far1 is a peroxisomal tail-anchored single-pass membrane protein whose hydrophobic C-terminus binds PEX19 for targeting; it is the rate-limiting enzyme for plasmalogen synthesis.
"Far1 is a rate-limiting enzyme for plasmalogen synthesis"
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
-
Large-scale yeast two-hybrid neurodegenerative-disease interactome; source of high-throughput FAR1 protein-protein interaction records (KLF11, BAG6, COL26A1 isoforms).
"systematic yeast two-hybrid"
FAR1 reduces PalmCoA to HXOL