CDF1 (CYCLING DOF FACTOR 1; DOF5.5; At5g62430; UniProtKB:Q8W1E3) notes

Identity check (2026-10-05)

A symbol search for CDF1 in A. thaliana returns two reviewed entries: Q9FN50 (CPP1, "CELL GROWTH
DEFECT FACTOR 1", At5g23040, chloroplastic) and Q8W1E3 (Cyclic dof factor 1, At5g62430). The
photoperiod-pathway CDF1 is Q8W1E3; the folder was fetched by accession
(just fetch-gene ARATH Q8W1E3 --alias CDF1). The uniprot.txt reads CDF1_ARATH, Name=CDF1; Synonyms=DOF5.5; OrderedLocusNames=At5g62430.
Falcon deep research failed (HTTP 402), so there is no deep-research file; the notes below come from
the cached publications.

Repressor of CO, degraded by FKF1: PMID:16002617 PMID:16002617
GI dependence: PMID:17872410 PMID:17872410
Direct FT repression: PMID:22628657 PMID:22628657
Mechanism via TOPLESS: PMID:28752516
Redundancy with other CDFs: PMID:19619493
Structure: PMID:40263610
Non-flowering outputs of the GI-CDF module: PMID:25600594; hypocotyl elongation in short days PMID:32379360

MF core: GO:0001227 (DNA-binding transcription repressor activity, RNA pol II-specific) + GO:0001222
(transcription corepressor binding; TPL).
FKF1/LKP2 protein-binding rows -> MODIFY to GO:0031625 ubiquitin protein ligase binding (CDF1 is the
SCF(FKF1) substrate).
GI protein-binding row -> REMOVE (term only; interaction real, no informative MF term).
Chloroplast organization IMP (PMID:22383539) -> UNDECIDED: abstract does not name CDF1, full text not
retrievable (Europe PMC returned 500).
NEW: GO:0048579 negative regulation of long-day photoperiodism, flowering. Entity check: CDF1 itself
binds the CO and FT promoters and represses them (it performs the regulatory step), so the regulation
term belongs on CDF1; comparator CO carries the positive counterpart GO:0048578.

Chloroplast organization IMP (PMID:22383539): the publication was re-fetched with full text from PMC
(just fetch-pmid 22383539 --force). The full text names CDF1 as an END (enhanced deetiolation) gene
PMID:22383539.
Changed UNDECIDED -> KEEP_AS_NON_CORE.