Refreshed the mouse Mapk1 GOA and UniProt snapshots and resolved 18 newly
seeded source rows. ERK2/MAPK1 remains a canonical RAS-RAF-MEK-ERK terminal
kinase whose core function is proline-directed serine/threonine MAP kinase
activity.
Four new GO:0005515 protein binding rows were removed. Three came from the
AfCS signaling-database review PMID:15102471 and one from the pseudorabies
virus Us2/ERK membrane-recruitment study PMID:20554783. The PMID:16148006 ERK2
docking-groove row was instead narrowed from generic binding to
GO:0019902 phosphatase binding because the abstract directly supports
selective ERK2 binding to MKP-3/DUSP6 phosphatase.
Accepted refreshed nucleoplasm, cytoplasm, and cytosol rows because they match
the established ERK2 nuclear-cytosolic shuttling model already used in the
review. Kept regulation of ossification and myelination as non-core
developmental ERK outputs; the new myelination row is from the neuregulin/ErbB
study PMID:18760695, consistent with the existing non-core myelination rows.
Handled the transferred pathway rows consistently with the existing review:
GO:0045542 positive regulation of cholesterol biosynthetic process and
GO:0045880 positive regulation of smoothened signaling pathway remain
over-annotations of narrow human crosstalk contexts, GO:0070371 ERK1 and ERK2
cascade is an accepted core cascade term, and three new GO:0106310 protein
serine kinase activity rows were narrowed to the more informative
GO:0004707 MAP kinase activity.
The legacy PMID:16148006 row with supporting entity UniProtKB:Q62132 was
narrowed from generic protein binding to GO:0019902 phosphatase binding
because Q62132 is Ptprr/PTP-SL, one of the ERK2 phosphatases whose docking
interface is distinguished from DUSP6/MKP-3 in that paper.
The PMID:10419510 row with the same UniProtKB:Q62132 PTP-SL supporting
entity was also narrowed to GO:0019902 phosphatase binding because the
abstract directly states that ERK1/2 associate with the PTP-SL kinase
interaction motif.