Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.

Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.

APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest.

A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis.

A reference map of the human binary protein interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL

TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC

Metallochaperone inserts Cu2+ into MT-CO1

MT-CO1 and MT-CO2 complexes associate, installing heme moieties

MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex

UniProtKB entry Q96I36 (COX14_HUMAN)