Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.
Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages.
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18).
JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration.
Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils.
Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.
Transforming growth factor-beta-induced gene product, as a novel ligand of integrin alphaMbeta2, promotes monocytes adhesion, migration and chemotaxis.
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides.
Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines.
cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits.
Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.
Pleiotrophin, a multifunctional cytokine and growth factor, induces leukocyte responses through the integrin Mac-1.
A reference map of the human binary protein interactome.
Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling.
Integrin alphaMbeta2 (MAC1) binds JAM3
Expression of IL13-upregulated plasma membrane proteins
Exocytosis of tertiary granule membrane proteins
Exocytosis of specific granule membrane proteins
Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18).
Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3.
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions.
A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation.
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia.
Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor.
Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.
UniProtKB entry P11215 (ITAM_HUMAN), Integrin alpha-M