Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Evidence for simultaneous protein interactions between human Rad51 paralogs.
The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2.
Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex.
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
Telomere maintenance requires the RAD51D recombination/repair protein.
Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.
Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination.
Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.
Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
Next-generation sequencing to generate interactome datasets.
hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Discovery of mutations in homologous recombination genes in African-American women with breast cancer.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.
Multimodal cell maps as a foundation for structural and functional genomics.
Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene.
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Ligation of DNA and formation of Holliday structures following repair synthesis
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
D-loop formation mediated by PALB2, BRCA2 and RAD51
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
Structural insights into BCDX2 complex function in homologous recombination.
RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases.
Cryo-electron microscopic visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2.
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation.
High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response.
Distinct functions of mammalian RAD51 paralogs in genome maintenance.
RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.
The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C.
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Walker A K113R and K113A mutations of mouse Rad51d strongly reduce ICL repair capacity in Rad51d-deficient MEFs, interpreted as showing that ATP binding and hydrolysis by RAD51D are required for ICL repair.
"These cell-based studies are the first evidence that ATP binding and hydrolysis by RAD51D are required for efficient HR repair of DNA interstrand crosslinks"
Germline mutations in RAD51D confer susceptibility to ovarian cancer.