Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Initial characterization of the nascent polypeptide-associated complex in yeast.
-
BTT1 encodes one of the yeast NAC beta subunits.
"The three subunits of the nascent polypeptide-associated complex (alpha, beta1, beta3) in Saccharomyces cerevisiae are encoded by three genes (EGD2, EGD1, BTT1)."
-
Yeast NAC binds ribosomes through its beta subunits near nascent polypeptides.
"BTT1). We found the complex bound to ribosomes via the beta-subunits"
-
NAC is positioned near nascent polypeptides.
"in close proximity to nascent polypeptides"
The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane.
-
NAC prevents inappropriate binding of signal-less ribosome-nascent-chain complexes to yeast membranes.
"We provide evidence that NAC prevents binding of RNCs without a signal sequence to yeast membranes."
-
Loss of NAC allows signal-less ribosome-nascent-chain complexes to bind ER membranes.
"In the absence of NAC, signal-less RNCs are able to bind to ER membranes."
A comprehensive two-hybrid analysis to explore the yeast protein interactome.
-
The cited source is a large two-hybrid interactome screen, so its Btt1 protein-binding annotation is low-specificity.
"A comprehensive two-hybrid analysis to explore the yeast protein interactome."
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
-
The cited source is a global protein complex map, supporting interaction context but not a specific Btt1 molecular activity.
"Global landscape of protein complexes in the yeast Saccharomyces cerevisiae."
Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes.
-
Btt1 was reported as a CCR4-NOT-associated protein interacting through Caf130.
"BTT1, a member of the nascent polypeptide association complex that binds the ribosome, was shown to be a tenth member of the CCR4-NOT complex"
-
Caf130 mediates the Btt1-CCR4-NOT interaction.
"interacting through CAF130"
Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae.
-
Yeast NAC and RAC-Ssb are ribosome-tethered systems assisting cotranslational folding.
"assist cotranslational processes such as folding of nascent polypeptides."
-
NAC loss in sensitized cells contributes to aggregation of newly synthesized proteins.
"aggregation of newly synthesized proteins"
The social and structural architecture of the yeast protein interactome.
-
The cited source is a proteome-scale interactome study, supporting interaction context but not a specific Btt1 molecular activity.
"The social and structural architecture of the yeast protein interactome."
Falcon deep research report on BTT1