HIS5 (YIL116W, P07172) notes

Pathway context: YeastPathways HISTSYN-PWY, step 7 (EC 2.6.1.9). YeastPathways also lists HIS5 in PWY3O-4115 (phenylalanine degradation transamination) and ALL-CHORISMATE-PWY-1.

• Identity: [UniProt:P07172 "RecName: Full=Histidinol-phosphate aminotransferase {ECO:0000305};"], class II PLP aminotransferase, PLP cofactor.
• Genetics: PMID:14190241.
• Aromatic transamination in yeast is Aro8/Aro9: PMID:9491082 -> HIS5 cannot substitute in vivo. No yeast experiment found showing His5 aromatic aminotransferase activity (WebSearch, Oct 2026). Bacterial HisC promiscuity is the likely basis of the pathway-database assignment.
• Decisions: aromatic-amino-acid transaminase RCA = MARK_AS_OVER_ANNOTATED; Phe catabolic process and chorismate metabolic process RCA = REMOVE; generic transferase/amino acid transaminase IEA -> MODIFY to GO:0004400.