Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
Human VPS34 and p150 are Rab7 interacting partners.
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
Regulation of membrane traffic by phosphoinositide 3-kinases.
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment.
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Defining the membrane proteome of NK cells.
The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication.
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
Network organization of the human autophagy system.
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression.
PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk.
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
The VMP1-Beclin 1 interaction regulates autophagy induction.
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.
Identification of a candidate therapeutic autophagy-inducing peptide.
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells.
NRBF2 regulates macroautophagy as a component of Vps34 Complex I.
NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
A kinase-independent role for EGF receptor in autophagy initiation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells.
Architecture of the human interactome defines protein communities and disease networks.
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication.
ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication.
Global Proximity Interactome of the Human Macroautophagy Pathway.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex.
The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes.
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.
PI3K-containing complexes phosphorylate PIP2 to PIP3
ULK1 phosphorylates AMBRA1:BECN1 complex
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
Rab5-mediated recruitment of class III PI3K to TLR9
Beclin-1 complex phosphorylates PtdIns
AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex
BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2
ULK1 phosphorylates Beclin-1
Beclin-1 complex translocates to the ER
The phagophore extends from the PIP3-enriched structure
PIK3C3:PIK3R4 phosphorylates PI to PI3P
SARS-CoV-2 8:class I MHC binds BECN1
Falcon deep research synthesis for PIK3C3
UniProt record for human PIK3C3
Reactome autophagy initiation event containing PIK3C3
OpenScientist focused adjudication of PIK3C3 pexophagy and peroxisome localization (recovered cancelled-job artifact)
The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae.
Manual full-text check of Grunau et al. PMID:21121900