Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
PANTHER PTHR12802 PAINT annotations
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PTN000301253 carries the current conserved SMARCC/SWI3 SWI/SNF-complex membership IBD assertion.
"PTHR12802 PTN000301253 GO:0016514 C IBD false MGI:MGI:1203524|MGI:MGI:1915344|PomBase:SPAC17G6.10|PomBase:SPAC23H3.10|SGD:S000003712|UniProtKB:Q8TAQ2|UniProtKB:Q92922 taxon: 20190305"
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PTN000301254 carries current IBD assertions for histone binding and positive DNA-templated-transcription regulation.
"PTHR12802 PTN000301254 GO:0042393 F IBD false SGD:S000003712 taxon:33154 20190305
PTHR12802 PTN000301254 GO:0045893 P IBD false FB:FBgn0002783|MGI:MGI:1203524|SGD:S000003712|UniProtKB:Q8TAQ2|UniProtKB:Q92922 taxon:33154 20250903"
Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription
Cell cycle control of the yeast HO gene cis and trans-acting regulators
Five SWI genes are required for expression of the HO gene in yeast
Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex
A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast
Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement
Generation of superhelical torsion by ATP-dependent chromatin remodeling activities
The nuclear actin-related proteins Arp7 and Arp9 a dimeric module that cooperates with architectural proteins for chromatin remodeling
Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast
Proteomic analysis of chromatin-modifying complexes in Saccharomyces cerevisiae identifies novel subunits
The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles
Proteome survey reveals modularity of the yeast cell machinery
Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement
Architecture of the SWI/SNF-nucleosome complex
The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation
Composition and Function of Mutant Swi/Snf Complexes
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
The social and structural architecture of the yeast protein interactome
SNF11, a new component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2
TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9
Subunits of the yeast SWI/SNF complex are members of the actin-related protein (ARP) family
Falcon (Edison) deep research report on SWI3 (YJL176C, P32591)
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SWI3 (YJL176C) is a core, non-catalytic structural/regulatory subunit of the
SWI/SNF chromatin remodeling complex; it is not an enzyme.
"SWI3 is **not an enzyme**; it is a **core structural/regulatory subunit** within SWI/SNF."
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The Swi3 SWIRM domain directly binds DNA (including cruciform/nucleosomal DNA)
with apparent Kd ~72-105 nM in vitro, and contributes to SWI/SNF assembly and stability.
"and a KD of **~105.36 ± 7.65 nM** reported for binding to cruciform DNA in vitro."
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Cryo-EM resolves two copies of Swi3 (Swi3A/Swi3B) that, with Swi1, form the
structural backbone of the complex; Swi3 SWIRM domains contact Snf5 RPT regions.
"The model contains **two Swi3 instances (Swi3A and Swi3B)**."
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Swi3 is predominantly nuclear under normoxia but relocalizes to the cytosol under
hypoxia (>95% cytosolic), reversing on reoxygenation.
"Swi3 is predominantly **nuclear** under normoxia but undergoes regulated **cytosolic relocalization under hypoxia** (>95% cytosolic)"
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Beyond activation, Swi/Snf (and Swi3) contributes to context-specific gene
repression via transcriptional interference, shown by the swi3-E815X allele.
"A 2024 Molecular Cell study found that SWI/SNF remodeling regulates transcriptional interference and gene repression."
Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae
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The Swi3 paralog Swh3 (which partners with Sth1 in an essential RSC-related
complex) is functionally distinct from Swi3 and does not substitute for it,
aiding disambiguation of SWI3 from SWI3-like proteins.
"Swh3 and Swi3 are functionally"
Structure of the yeast Swi/Snf complex in a nucleosome free state
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Cryo-EM shows the conserved subunits Swi1 and Swi3 form the backbone of the
Swi/Snf complex, with a Swi3 dimer (coiled-coils, SANT, SWIRM domains)
enwrapping Swi1.
"Swi1 and Swi3 form the backbone of the complex and closely connect with surrounding subunits."
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The Snf5 RPT domains interact with the SWIRM domains of Swi3A and Swi3B by
electrostatic interaction within the nucleosome-binding module.
"interact with the SWIRM domains of Swi3A and Swi3B by electrostatic interaction"
Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression
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Swi/Snf chromatin remodeling is required for co-transcriptional nucleosome
remodeling that drives LUTI-based gene repression via transcriptional interference.
"playing a direct role in gene repression via a cis transcriptional interference"
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The swi3-E815X allele (a nonsense mutant of the structural subunit Swi3)
reduces Swi/Snf repressive activity at proximal TSSs, though less strongly
than the snf2-W935R ATPase mutant.
"swi3-E815X mutation also reduces repressive activity by Swi/Snf at the TSSPROX but to a lesser extent than the snf2-W935R mutant."