glo-1 review notes
- 2026-10-28: fetch-gene resolved G5EBF0 (WormBase WBGene00011083, GeneID 3565633); GOA has 17 rows.
- PMID:15843430 and PMID:17202409 are abstract-only in the cache (PMC refused full text);
PMID:22916203, 23705068, 30419011, 24501423, 39078368, 31848222, 37704756 have full text.
- PMID:23705068 (Zhu et al. 2013, sphingolipid-TORC1) uses ges-1p::glo-1::GFP only as a lysosome
marker: PMID:23705068
It does not test GLO-1 function.
- Decisions:
- GTPase activity: ACCEPT (Rab family; Q71 catalytic Gln present; Q71L/T25N genetics PMID:30419011).
- GTP binding: ACCEPT (GEF-driven nucleotide exchange in vitro PMID:39078368).
- Lysosome organization (IMP): MODIFY to gut granule assembly GO:1902900; GO places gut granule
assembly under vesicle/organelle assembly, not lysosome organization, and glo-1 does not affect
conventional endolysosomes PMID:30419011.
- Lipid storage (IMP, abstract only): MARK_AS_OVER_ANNOTATED; downstream of organelle loss.
- Mitochondrion/Golgi/TGN: MARK_AS_OVER_ANNOTATED (mammalian paralog localizations).
- Generic CC (cytoplasm, membrane, vesicle, endomembrane system): MODIFY to gut granule (membrane).
- Comparator check not needed: no NEW process terms proposed.