Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV.
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ParC and ParE purified separately reconstitute an ATP-dependent decatenating and relaxing topoisomerase IV without supercoiling activity, less sensitive to quinolones than gyrase.
"These results confirmed that topoisomerase IV is less sensitive to fluoroquinolones than is DNA gyrase and may be a secondary target of new quinolones in wild-type P. aeruginosa."
UniProt record Q9HUJ8 (parE)