Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation of UniProtKB entries based on the manual curation of subcellular locations
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues.
Interaction of human HSP22 (HSPB8) with other small heat shock proteins.
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HSPB8 (HSP22) hetero-dimerizes with cvHSP (HSPB7) through a C-terminal to C-terminal interaction, and also interacts with HSPB2 (MKBP) and HSPB1 (HSP27), defining the small-HSP hetero-oligomer network.
Towards a proteome-scale map of the human protein-protein interaction network.
HSPB7 is a SC35 speckle resident small heat shock protein.
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HSPB7 constitutively localizes to SC35 nuclear splicing speckles driven by its N-terminus and, unlike HSPB1/HSPB5, does not support refolding of heat-denatured substrates, indicating a non-canonical chaperone role.
HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones.
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HSPB7 was the strongest HSPB-family suppressor of expanded-polyQ aggregation and toxicity in cells, acting early in aggregate formation through a noncanonical, autophagy-dependent mechanism rather than by improving refolding.
The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation-suppressing activity.
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Recombinant HSPB7 directly delayed polyQ aggregation in vitro, and its N-terminal domain was necessary and sufficient for binding polyQ-containing proteins and suppressing their aggregation.
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Co-immunoprecipitation indicated binding to early profibrillar species; the authors propose that this interaction delays further oligomerization or stabilizes protofibrils for autophagic clearance.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
UniProt entry Q9UBY9 (HSPB7_HUMAN), Heat shock protein beta-7 (cvHsp)