Gene Ontology annotation through association of InterPro records with GO terms

The actual InterPro family record includes the magnesium-homeostasis mapping; target experiments provide independent support.

Annotation inferences using phylogenetic trees

Current donor identities, exact same-term records and PTN-bearing annotations were inspected. This is not a reconstruction of historical PAINT node placement.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

The fetched UniProt plasma-membrane location and source mapping were checked against independent target evidence.

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

Actual HPA XML contains plasma-membrane calls with uncertain reliability; independent human CNNM4 experiments corroborate that location.

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

The named mouse donor and Ensembl protein resolve together, with exact relevant source records. Human target experiments independently support the decisions.

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

The two process assertions correspond to actual sodium and magnesium transport, with their original inference sources preserved.

PMID:15840172

Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis.

Separate prey retests establish RBM30/RBM4B and COX11 interactions. Metal-toxicity changes are indirect homeostasis evidence; the proposed transfer mechanism remains unresolved.

PMID:24339795

Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model.

Human CNNM4 drives sodium-coupled magnesium efflux; mouse knockout establishes intestinal magnesium-balance phenotypes.

PMID:42497866

Dynamic dimer-of-dimers architecture defines Mg(2+) transport in human CNNM4.

Full-length human CNNM4 forms an MgATP-bound dimer-of-dimers; surface-controlled mutations impair magnesium efflux.

PMID:34928937

CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells.

Human CNNM4 associates with TRPM7 and restores channel currents and magnesium uptake independently of its magnesium-lowering function.

PMID:40962059

The cytoplasmic domains of the CNNM family of transmembrane proteins modulate the ion channel-kinase TRPM7.

Human CNNM4 S196P and CBS-deletion variants retain TRPM7 current-rescue activity, separating channel regulation from magnesium efflux.

PMID:24706765

Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter.

Human CNNM4 CBS domains bind ATP in a magnesium-dependent assay; CBS deletion impairs magnesium efflux.

PMID:37449820

Structural insights into regulation of CNNM-TRPM7 divalent cation uptake by the small GTPase ARL15.

Human CNNM4 CBS-containing fragments bind ARL15; interface mutants lose that interaction.

PMID:19200525

Mutations in CNNM4 cause Jalili syndrome, consisting of autosomal-recessive cone-rod dystrophy and amelogenesis imperfecta.

Biallelic CNNM4 variants segregate with Jalili syndrome; affected human teeth have reduced mineralization.

PMID:19200527

Mutations in CNNM4 cause recessive cone-rod dystrophy with amelogenesis imperfecta.

Human recessive CNNM4 variants cause combined cone-rod dystrophy and amelogenesis imperfecta.

PMID:22399287

Membrane topology and intracellular processing of cyclin M2 (CNNM2).

Sequence-verified human CNNM4 has a plasma-membrane distribution and intracellular C terminus in the permeabilization assay.

PMID:25347473

Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.

PRL binding inhibits human CNNM4-dependent magnesium efflux and modulates intracellular magnesium in cultured cells.

file:human/CNNM4/CNNM4-source-evidence.json

CNNM4 source records and evidence scope

Source locators, exact current annotation records, isoform reconstruction and access limits are recorded for reproducibility; biological findings are supported by primary references.