Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Hepatitis C virus core protein interacts with a human DEAD box protein DDX3.
A proinflammatory cytokine inhibits p53 tumor suppressor activity.
The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C.
Naked cuticle targets dishevelled to antagonize Wnt signal transduction.
Negative control of p53 by Sir2alpha promotes cell survival under stress.
Design and application of a cytokine-receptor-based interaction trap.
p53 has a direct apoptogenic role at the mitochondria.
Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis.
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.
The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein.
Interaction of nucleoside diphosphate kinase and catalases for stress and light responses in Neurospora crassa.
Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip).
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.
Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha.
BAF60a interacts with p53 to recruit the SWI/SNF complex.
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.
The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.
Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.
Trim24 targets endogenous p53 for degradation.
Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein.
Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase (Tgs1p).
Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity.
DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc.
Puma is required for p53-induced depletion of adult stem cells.
An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.
p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response.
Interaction of Sesbania mosaic virus movement protein with the coat protein--implications for viral spread.
Near-UV cyanobacteriochrome signaling system elicits negative phototaxis in the cyanobacterium Synechocystis sp. PCC 6803.
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation.
Structural basis for the molecular evolution of SRP-GTPase activation by protein.
Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells.
p53 opens the mitochondrial permeability transition pore to trigger necrosis.
Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells.
Deacetylation of p53 induces autophagy by suppressing Bmf expression.
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.
p53 regulates Period2 expression and the circadian clock.
The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.
FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage.
Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage.
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.
The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873.
The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner.
p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop.
Arabidopsis LFR, a SWI/SNF complex component, interacts with ICE1 and activates ICE1 and CBF3 expression in cold acclimation.
Binding and modulation of p53 by p300/CBP coactivators.
Dppa2 and Dppa4 bind the Dux gene cluster
UniProt record for mouse Trp53
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Trp53 encodes p53, a multifunctional transcription factor that induces cell cycle arrest, DNA repair, or apoptosis after binding target DNA sequences.
"Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence."
Falcon deep research report on mouse Trp53
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Falcon synthesis verifies mouse Trp53/p53 as a sequence-specific DNA-binding transcription factor with tissue- and stress-specific outputs.
"Mouse Tp53 (Trp53; UniProt P02340) encodes p53, a stress-activated, sequence-specific DNA-binding transcription factor."