Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes.
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LPCAT1 (Aytl2) characterized as PC-reacylating enzyme in erythrocytes
"Characterization of the product of the Aytl2 gene as the phosphatidylcholine reacylating enzyme in RBCs represents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the function of a LPCAT protein."
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Generated PC from long-chain acyl-CoA and lysoPC substrates
"The three murine Aytl proteins generated phosphatidylcholine from long-chain acyl-CoA and lysoPC when expressed in Escherichia coli membranes."
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Calcium and magnesium modulate LPCAT activity
"Calcium and magnesium modulated LPCAT activity of both Aytl1 and -2 proteins that exhibit EF-hand motifs at the C terminus."
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Contains EF-hand motifs at C-terminus
"Calcium and magnesium modulated LPCAT activity of both Aytl1 and -2 proteins that exhibit EF-hand motifs at the C terminus."
Defining the membrane proteome of NK cells.
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LPCAT1 identified in membrane proteome of NK-like cells
"Mass spectrometric analysis identified 1843 proteins with high confidence scores...approximately 40% of the identified proteins were predicted as plausible membrane proteins."
Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.
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LPCAT1 and LPCAT2 localize to both ER and lipid droplets
"Here, we show in various mammalian cell lines that both enzymes additionally localize to lipid droplets (LDs), which consist of a core of neutral lipids surrounded by a monolayer of phospholipid, mainly PC."
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Dual localization enabled by monotopic membrane topology
"This dual localization is enabled by the monotopic topology of these enzymes demonstrated in this study."
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Lipid droplets can locally synthesize PC
"Furthermore, we show that LDs have the ability to locally synthesize PC and that this activity correlates with the LPCAT1 and -2 expression level."
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PC synthesis activity correlates with LPCAT1/2 expression
"Furthermore, we show that LDs have the ability to locally synthesize PC and that this activity correlates with the LPCAT1 and -2 expression level."
2-acyl LPC is acylated to PC by LPCAT
1-acyl LPG is acylated to PG by LPGAT
1-acyl LPC is acylated to PC by LPCAT
2-acyl LPG is acylated to PG by LPGAT
Acyl chain remodelling of PC
Acyl chain remodelling of PG
Exocytosis of azurophil granule membrane proteins
1-acyl LPA is acylated to PA by AGPAT (LPAAT)
STARD10 transports PC from ER membrane to lamellar body membrane
STARD10 binds LPCAT1 and PC
Deep research on LPCAT1 function