Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

PMID:18804378

The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.

Combined let-363/TOR and daf-15/Raptor RNAi from L4 extends lifespan, and the extension requires pha-4/FoxA; daf-15 mutants share small nucleoli and lipid accumulation with let-363.

PMID:3350212

Mutants of Caenorhabditis elegans that form dauer-like larvae.

daf-15(m81) forms incomplete dauer-like larvae that cannot exit arrest; daf-15 is epistatic to dauer-defective mutations.

PMID:23705068

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans.

A DAF-15::RAP-1(22) fusion (Raptor with a lysosome-targeting tail) constitutively activates TORC1 and bypasses mmBCFA-deficiency L1 arrest.

PMID:15253933

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.

daf-15 encodes raptor; raptor and CeTOR mutants arrest as dauer-like larvae, accumulate fat, and raptor mutations extend lifespan; daf-15 transcription is regulated by DAF-16/FOXO.

PMID:22278922

S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells.

Reducing let-363/TOR or daf-15/Raptor activity reduces the larval germline progenitor pool, similarly to loss of rsks-1 plus ife-1.

file:worm/daf-15/daf-15-uniprot.txt

UniProt record G5EEV7 (daf-15)

file:worm/daf-15/daf-15-deep-research-manual.md

Manual literature research for daf-15