Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
Nudix-type RNA pyrophosphohydrolase provides homeostasis of virulence factor pyocyanin and functions as a global regulator in Pseudomonas aeruginosa.
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PA0336 complements an E. coli rppH defect, indicating it mediates RNA turnover in vivo.
"Trans-complementation experiments showed that the P. aeruginosa enzyme can functionally substitute for RppH in E. coli cells indicating that, similar to RppH, the Pseudomonas hydrolase mediates RNA turnover in vivo."
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The pyocyanin phenotype of the mutant requires the catalytic activity for complementation.
"This phenotype was reversed by complementation with the wild type but not catalytically inactive PA0336, indicating that the catalytic activity was indispensable for its biological function."
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Loss of PA0336 changes the level of 537 transcripts.
"The level of 537 transcripts coding for proteins involved in a variety of cellular processes"
UniProt entry Q9X4P2
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HAMAP-curated function of the RppH subfamily.
"Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage."
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Family placement.
"Belongs to the Nudix hydrolase family. RppH subfamily."