Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

TreeGrafter-generated GO annotations

Combined Automated Annotation using Multiple IEA Methods

Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites.

Lin28 proteins are required for germ layer specification in Xenopus.

lin28 proteins promote expression of 17∼92 family miRNAs during amphibian development.

The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone function.

Overexpression of Lin28a delays Xenopus metamorphosis and down-regulates albumin independently of its translational regulation domain.

Characterisation of the fibroblast growth factor dependent transcriptome in early development.

TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.

Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.

Selective blockade of microRNA processing by Lin28.

Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules.

Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes.

Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis.

Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells.

Shared features of blastula and neural crest stem cells evolved at the base of vertebrates.

NEURODEVELOPMENT. Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells.

UniProt entry Q8JHC4 (LN28A_XENLA)

Deep research report on Xenopus laevis lin28a (falcon)