FLNC source and context guide

All 32 original contexts and both natural products remain preserved. This guide retains their original identifiers and full source objects; the two original extensions omitted by the genuine seed projection are now also rehydrated in the structured review YAML. No source field is corrected by interpretation.

Original context mapping

Stored row (0-based)	Raw index	Original context ID	Term	Evidence	Reference	Assigned by	Partners	Extensions	Decision
0	0	UniProtKB:Q14315!447160608	GO:0005515	IPI	PMID:11038172	IntAct	UniProtKB:Q9UBF9	null	MODIFY
1	1	UniProtKB:Q14315!447160609	GO:0005515	IPI	PMID:16076904	UniProt	UniProtKB:P05556	null	MODIFY
2	2	UniProtKB:Q14315!447160610	GO:0005515	IPI	PMID:16076904	UniProt	UniProtKB:Q9NP98	null	MODIFY
3	3	UniProtKB:Q14315!447160611	GO:0005515	IPI	PMID:16076904	UniProt	UniProtKB:Q9UBF9	null	MODIFY
4	4	UniProtKB:Q14315!447160612	GO:0005515	IPI	PMID:16631741	IntAct	UniProtKB:Q702N8	[{"connectedXrefs":[{"db":"GO","id":"0014704","relation":"occurs_in"}]}]	MODIFY
5	5	UniProtKB:Q14315!447160613	GO:0005515	IPI	PMID:17474147	IntAct	UniProtKB:P00519	null	MODIFY
6	6	UniProtKB:Q14315!447160614	GO:0005515	IPI	PMID:17474147	IntAct	UniProtKB:P46108	null	MODIFY
7	7	UniProtKB:Q14315!447160615	GO:0005515	IPI	PMID:17474147	IntAct	UniProtKB:P62993	null	MODIFY
8	8	UniProtKB:Q14315!447160616	GO:0005515	IPI	PMID:21223964	IntAct	UniProtKB:O70511-7	null	MODIFY
9	9	UniProtKB:Q14315!447160617	GO:0005515	IPI	PMID:22972877	IntAct	UniProtKB:Q6P050	null	KEEP_AS_NON_CORE
10	10	UniProtKB:Q14315!447160618	GO:0005515	IPI	PMID:33961781	IntAct	UniProtKB:Q9BY42	null	KEEP_AS_NON_CORE
11	20	UniProtKB:Q14315!447160628	GO:0005737	IDA	PMID:12393796	MGI		null	TOO_GENERAL
12	21	UniProtKB:Q14315!447160629	GO:0005737	IDA	PMID:25351925	UniProt		null	TOO_GENERAL
13	19	UniProtKB:Q14315!447160627	GO:0005737	IEA	GO_REF:0000044	UniProt	UniProtKB-SubCell:SL-0086	null	TOO_GENERAL
14	22	UniProtKB:Q14315!447160630	GO:0005829	IDA	GO_REF:0000052	HPA		null	ACCEPT
15	23	UniProtKB:Q14315!447160631	GO:0005829	TAS	Reactome:R-HSA-430347	Reactome		null	ACCEPT
16	24	UniProtKB:Q14315!447160632	GO:0005856	IEA	GO_REF:0000044	UniProt	UniProtKB-SubCell:SL-0090	null	MODIFY
17	25	UniProtKB:Q14315!447160633	GO:0005925	HDA	PMID:21423176	UniProt		[{"connectedXrefs":[{"db":"CL","id":"0000057","relation":"part_of"}]}]	KEEP_AS_NON_CORE
18	11	UniProtKB:Q14315!447160619	GO:0008092	IPI	PMID:17987659	UniProt	UniProtKB:O76041	null	KEEP_AS_NON_CORE
19	12	UniProtKB:Q14315!447160620	GO:0008092	IPI	PMID:17987659	AgBase	UniProtKB:Q90684	null	KEEP_AS_NON_CORE
20	26	UniProtKB:Q14315!447160634	GO:0016020	IEA	GO_REF:0000044	UniProt	UniProtKB-SubCell:SL-0162	null	TOO_GENERAL
21	27	UniProtKB:Q14315!447160635	GO:0016528	IEA	GO_REF:0000107	Ensembl	UniProtKB:D3ZHA0; ensembl:ENSRNOP00000027237	null	ACCEPT
22	28	UniProtKB:Q14315!447160636	GO:0030018	IEA	GO_REF:0000044	UniProt	UniProtKB-SubCell:SL-0314	null	ACCEPT
23	16	UniProtKB:Q14315!447160624	GO:0030036	IEA	GO_REF:0000120	UniProt	ARBA:ARBA00028209; InterPro:IPR044801	null	ACCEPT
24	13	UniProtKB:Q14315!447160621	GO:0030506	IEA	GO_REF:0000107	Ensembl	UniProtKB:D3ZHA0; ensembl:ENSRNOP00000027237	null	KEEP_AS_NON_CORE
25	14	UniProtKB:Q14315!447160622	GO:0030506	IPI	PMID:21223964	BHF-UCL	UniProtKB:O70511	null	KEEP_AS_NON_CORE
26	30	UniProtKB:Q14315!447160638	GO:0042383	IDA	PMID:21223964	BHF-UCL		null	ACCEPT
27	29	UniProtKB:Q14315!447160637	GO:0042383	IEA	GO_REF:0000107	Ensembl	UniProtKB:D3ZHA0; ensembl:ENSRNOP00000027237	null	ACCEPT
28	31	UniProtKB:Q14315!447160639	GO:0043034	TAS	PMID:21223964	BHF-UCL		null	ACCEPT
29	17	UniProtKB:Q14315!447160625	GO:0045214	IMP	PMID:34405687	UniProt		null	ACCEPT
30	15	UniProtKB:Q14315!447160623	GO:0051015	IEA	GO_REF:0000002	InterPro	InterPro:IPR044801	null	ACCEPT
31	18	UniProtKB:Q14315!447160626	GO:0055001	IEA	GO_REF:0000107	Ensembl	UniProtKB:Q8VHX6; ensembl:ENSMUSP00000099139	null	KEEP_AS_NON_CORE

Normal source closure

All source files are genuine tool outputs and are immutable in this review. Existing main objects were reused exactly. A full-text cache flag does not imply that figures, supplements or all sections were independently audited.

Source path	Bytes	SHA256
interpro/panther/PTHR38537/PTHR38537-entries.csv	1400	ba70c216fb6ab37e81465154cf69fd40ff5b822e50733d53a8fd01fe1bfbd736
interpro/panther/PTHR38537/PTHR38537-metadata.yaml	1024	37a92212a0eedbc880387224659c7b4a9b87b75f6afbe68c0c83b85217973bfd
interpro/panther/PTHR38537/PTHR38537-paint.tsv	149	81bace123a0fd1cea473868e21271eee8330bc086cd8ae7752ce0bdac04e9661
publications/PMID_11038172.md	116754	20e88c26c88aab4170434d46216330f5105d0f4067a4cb811347c06442e84c9a
publications/PMID_12393796.md	3082	fb8bfb9dec982f3603ef41b2a1aea4f5b9de7f7288b8cff11666c16a1ceeb75b
publications/PMID_16076904.md	3014	b63ef493d8f7b666f625c5d5751fb7d9140240f76323eef6e4b5b970951ffede
publications/PMID_16631741.md	2520	ad38e74ffc959e16f3c83fe268cbeff3fddc8bfe27a4b435af7858a02792f0e4
publications/PMID_16914736.md	2586	6baf6c1ffc4e4357e8aa952010188068fe6b62bb2eb5a8a81914ea96215b5ac0
publications/PMID_17474147.md	2788	c3fdff162d5aad9393123ae3de2f041784929f80054b8b7eeb28ef6487851872
publications/PMID_17987659.md	1750	136f41798f8182755fd66f38bc76354f8d6b0b67f6c886248fa9a1ef8c49351b
publications/PMID_21223964.md	3257	c086bf40299ca39eec1594f54482aa7a86a26a58f8842d1d8ac2a2145f9c5b8b
publications/PMID_21423176.md	65771	b07fc29f18f0735f07a19d469e7bdf8ba7f71a211f3b6f423f91e3dfc6170847
publications/PMID_22972877.md	3617	c32b450e047ab72fce82adc98fdbdc6dc728acd7fdcd87c10d919b06e5a028b4
publications/PMID_25351925.md	3144	e965e10e1ada0b8381f12133f3e6a4894e0ad6a12417fbad11533b325f4a5734
publications/PMID_33961781.md	10060	4763a1c8018e1b047fc1c2bf3d0e72c837e4b4c3dffbed428befa479e1c92286
publications/PMID_34405687.md	103171	5ffc1a9d52018e8a201d15cec03de855c2563c849e4f0e5122d7c0da032d7af8
reactome/R-HSA-430347.md	1177	7d15b4b71ba9b27604bf54b71a1a63636198f17caec3f89b2cc93a4626a6683c

Reading and ontology scope

PMID:11038172(https://pubmed.ncbi.nlm.nih.gov/11038172/) — Selected original Methods, Results and Discussion read, including purified human FLNC/myotilin fragment assays and endogenous human muscle localization. Human constructs in rat cardiomyocytes or mouse C2C12 cells are distinct. No figure-pixel or separate supplement audit; historical paralog language is not a modern natural-product assignment. Normal full-text flag: true.
PMID:12393796(https://pubmed.ncbi.nlm.nih.gov/12393796/) — PMID/title identity is verified. Selected original author-copy sections establish FLNA/FLNB interactions, but a FLNC-specific assay was not independently recovered. The inherited cytoplasm assertion is retained as biologically correct but TOO_GENERAL using independent target localization; exact source-specific FLNC support remains unverified, without a wrong-paralog accusation. Normal full-text flag: false.
PMID:16076904(https://pubmed.ncbi.nlm.nih.gov/16076904/) — Authentic original abstract explicitly reports FLNC C-terminal contacts with beta1A integrin, myotilin and FATZ1. Full pair-specific Methods, simultaneous ternary engagement, stoichiometry and natural-product mapping were not recovered. Normal full-text flag: false.
PMID:16631741(https://pubmed.ncbi.nlm.nih.gov/16631741/) — Authentic original abstract and exact human-pair IntAct yeast/far-western records support FLNC-Xin association. Microscopy is separate colocalization evidence. Full original Methods were not recovered; Xin interfaces, splice behavior and partner functions are not transferred to FLNC. Normal full-text flag: false.
PMID:17474147(https://pubmed.ncbi.nlm.nih.gov/17474147/) — Original abstract and six exact positive IntAct peptide-array pair records read, with official ABL1/CRK/GRB2 SH3 coordinates. Complete primary target tables were not recovered. Curated fragment evidence is explicitly distinguished from the abstract and from an endogenous full-length interaction. Normal full-text flag: false.
PMID:17987659(https://pubmed.ncbi.nlm.nih.gov/17987659/) — Original abstract and exact fetched record read; it explicitly identifies the nebulette-FLNC interaction. Full pair-specific construct/species allocation was not recovered. Original human and chicken partner contexts are preserved. Normal full-text flag: false.
PMID:21223964(https://pubmed.ncbi.nlm.nih.gov/21223964/) — Original abstract reports ankyrin-G OTBD screening, muscle co-IP and costamere colocalization. Full primary Methods/images were unavailable. Rat Ank3 and donor D3ZHA0 records remain distinct from independent human muscle localization; exact O70511-7 assay mapping is unresolved. Normal full-text flag: false.
PMID:21423176(https://pubmed.ncbi.nlm.nih.gov/21423176/) — Selected actual Methods/Results in the normal full-text cache read. Human HFF1 focal-adhesion fractions identify filamin-C with myosin-II-responsive enrichment. Fraction proteomics is not target-specific imaging or an isolated mechanosensing assay. Normal full-text flag: true.
PMID:22972877(https://pubmed.ncbi.nlm.nih.gov/22972877/) — Original abstract identifies FLNC as a potential FBXL22 substrate and reports dose-dependent degradation with proteasome-inhibitor attenuation. Confirmed SKP1/CUL1 co-IP is not silently reassigned to FLNC; exact FLNC pair-specific Methods remain unrecovered. Normal full-text flag: false.
PMID:25351925(https://pubmed.ncbi.nlm.nih.gov/25351925/) — Selected original author-repository PDF Methods/Results and Fig4 caption read. Tagged full-length human NM_001458 FLNC was tested in rat cardiac cells and additional mouse C2C12 assays. Engineered disease substitutions and pathological aggregation do not define natural product function; no image-pixel or separate SI audit. Normal full-text flag: false.
PMID:33961781(https://pubmed.ncbi.nlm.nih.gov/33961781/) — Original study metadata/available text and two exact human-pair IntAct anti-tag affinity-purification records support RTF2-FLNC complex association in HCT116 and HEK293T. The latter is a spoke-expanded edge. No spectrum reanalysis, direct binary affinity or complete pair-specific Methods replay is claimed. Normal full-text flag: true.
PMID:34405687(https://pubmed.ncbi.nlm.nih.gov/34405687/) — Selected original BioC Methods/Results/Discussion and caption context read. Isogenic human FLNC-null hiPSC cardiomyocytes show persistent sarcomere/actin disorganization, distinct from heterozygous variant behavior in the same conditions. No figures, videos or separate supplements were audited. Normal full-text flag: true.
PMID:16914736(https://pubmed.ncbi.nlm.nih.gov/16914736/) — Original abstract and exact official mouse Q8VHX6 donor annotation read. C2C12 differentiation/fusion and Flnc-deficient mouse myogenesis evidence support the transferred developmental context. Full original Methods were not independently read; no human developmental experiment is asserted. Normal full-text flag: false.

Official definitions and is_a/part_of ancestry support the authored classes cytoskeletal protein binding, FATZ binding, integrin binding, SH3 domain binding and ankyrin binding. The retained cytosol-to-cytoplasm and sarcolemma-to-membrane ancestor paths justify the four broad-location decisions.

The two official UniProt FASTAs establish product lengths 2725/2692 and the exact 1734–1766 deletion. There is no universal product-function assignment. The six positive SH3-array pairs are inspectable through IntAct; source-specific methods, endpoints and limits are summarized in the evidence synthesis.

PTHR38537 was genuinely obtained during accepted FLNA curation. Its complete family topology and original IBD GAF replay yielded a real single plant-branch record, outside the human path. FLNC has no incoming IBA; the family record is preserved and does not manufacture a new assertion. PANTHER family, Original PANTHER IBD GAF.

Review input provenance

The private preparation and independent peer records are retained locally; the durable content hashes below identify the precise accepted inputs without embedding local absolute paths.

FLNC-root-complete-matrix-20261028-v1/decision-matrix-v2.json: bc93fe181bba0e3f2ff545a793315a062bce869390c0569341bcbdfd01866627
FLNC-root-complete-matrix-20261028-v1/source-scope-and-core-proposal-v2.json: 734eb03b65d545b17e8b0cb1302bc6167d945640da2eb50ab2dc40e28631b487
FLNC-root-complete-matrix-20261028-v1/root-specificity-acceptance-v2.json: b2b5f142428c6040f2fcab005f65de6be2363e7805a6e16c8362244a6d4ec6b6
FLNC-root-complete-matrix-20261028-v1/root-core-scope-disposition.json: 53d6ee7c8a06e0e9e153da6cade1c6b955eccc7dc781831178db4dce25995253
FLNC-binding-specificity-peer-tracker642-20261028-v1/integrated-nine-row-peer.json: 81da63a97305413ea4f06d1a1c14acc16ecebf2723cb6d5800ea692924de2a49
FLNC-core-consultation-fhod3-20261028-v1/HANDOFF.json: 35641919669fc2277ebc040db34a7a9c462135d19bacb016a06e60baaed5b33c
FLNC-review-20261028-v1/FLNC-ai-review.yaml.seed: 24fbd1fe57d705865bf7b8540dc7594ef742dc063dabe266383ff51fb8fca5aa
FLNC-review-20261028-v1/context-projection-proof.json: 9b9c080f34d05314b0e707e48511252def34800fedbbf67ced9e2037dd55bc80
FLNA-review-20261028-v1/paint-replay-proof.json: a359561a2adfd132a915e10432a72f33142872966f732566d3f28f4abcdc883c

Follow-up ontology and context recovery

The source extensions are exact recoveries of original raw4/stored4 and raw25/stored17, using BFO:0000066 occurs in and BFO:0000050 part of. Official labels are GO:0014704 intercalated disc and CL:0000057 fibroblast. All remaining original source fields and all normal-source hashes above are unchanged.

GO:0015629 actin cytoskeleton directly is_a GO:0005856 and includes actin-associated proteins. Source-specific localization supports the refined stored16 decision. The core process path is GO:0045214 is_a GO:0031032 is_a GO:0030036; it explains the broader accepted process without adding a duplicate core entry. The evidence synthesis records exact primary locators and the turnover/crosslinking limits. Final counts are 10 ACCEPT, 8 KEEP_AS_NON_CORE, 10 MODIFY and 4 TOO_GENERAL; two original extensions are now queryable in YAML.

Follow-up proposal: af4127dfbfd80d4b19dc3bbbcbd689cbe9635ce5b204b8d0f4ce8ce884914c21
Official ontology peer: a726febc8a43f6a1fe05df28dd63b4c5cbafc7f7b0540a3e2890760e65bb49a0