Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads.
A novel missense mutation in the HSD3B2 gene, underlying nonsalt-wasting congenital adrenal hyperplasia. new insight into the structure-function relationships of 3β-hydroxysteroid dehidrogenase type II.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
UniProtKB P26439 (3BHS2_HUMAN) HSD3B2 record
-
HSD3B2 is a bifunctional NAD+-dependent enzyme catalyzing the dehydrogenation and Delta5-Delta4 isomerization steps common to synthesis of all steroid hormone classes.
"3-beta-HSD is a bifunctional enzyme, that catalyzes the"
-
Localized to the endoplasmic reticulum membrane as a single-pass membrane protein, with reported mitochondrion-membrane localization; expressed in adrenal gland, testis and ovary.
"SUBCELLULAR LOCATION: Endoplasmic reticulum membrane"
Pregn-5-ene-3,20-dione isomerizes to progesterone
HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST
Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione
17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol