Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Catalytic properties of polymorphic human cytochrome P450 1B1 variants.
Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.
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Recombinant human CYP1B1 Supersomes oxidize retinol to retinal. This directly measured activity is distinct from the paper's proposed extrahepatic physiological contribution and from the main hepatic CYP1A2/CYP3A4 contribution.
"CYP1A1 and CYP1B1 SUPERSOMES both exhibited exceptionally high
activities"
Characterization and functional analysis of two common human cytochrome P450 1B1 variants.
Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1.
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Human CYP1B1 reconstitution oxidizes retinoids and generates multiple arachidonate products. Table 3, human CYP1B1 column, resolves EET regioisomer percentages but groups some terminal HETE products; it does not determine EET stereochemistry.
"retinol to retinal and retinal to retinoate"
MicroRNA regulates the expression of human cytochrome P450 1B1.
Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1.
Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation.
Specificity determinants of CYP1B1 estradiol hydroxylation.
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Modified human CYP1B1 with human POR forms both estradiol hydroxylation products but favors C4; Val395 substitution changes this regioselectivity. Species and engineered variants are distinguished from the displayed human product.
"human CYP1B1 greatly favors 4-hydroxylation."
Angiopoietin receptor TEK interacts with CYP1B1 in primary congenital glaucoma.
CYP1B1 4-hydroxylates EST17b
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Arachidonate is hydroxylated to 16-HETE by CYP(1)
Arachidonate is hydroxylated to 19-HETE by CYP(2)
Arachidonate is epoxidated to 5,6-EET by CYP(4)
Arachidonate is epoxidated to 8,9-EET by CYP(5)
Arachidonate is hydroxylated to 20-HETE by CYP(3)
Defective CYP1B1 does not 4-hydroxylate EST17b
Arachidonate is epoxidated to 11,12-EET by CYP(5)
Arachidonate is hydroxylated to 17-HETE by CYP(1)
Arachidonate is hydroxylated to 18-HETE by CYP(1)
Arachidonate is epoxidated to 14,15-EET by CYP(5)
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Role of THR501 residue in substrate binding and catalytic activity of cytochrome P4501A1.
7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.
Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.
The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms.
CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression.
CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress.
Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.
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Commercial human CYP1B1 Supersomes produce chiral EET products: original Table 2 separately identifies the human enzyme row and shows enrichment of 8R,9S and 14R,15S products, with both 11,12 enantiomers. Mouse Hepa-cell results do not isolate human CYP1B1.
"P4501B1-mediated conversion of AA into EETs"
Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.
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Original Table 2 and the eicosanoid-metabolism Methods directly establish human CYP1B1 microsomal hydroperoxide conversion, although the title emphasizes CYP2S1. The target assays omit added NADPH but retain POR; purified CYP2S1 controls and inflammatory interpretation are not transferred to CYP1B1.
Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells.
Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.
Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells.
Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B1.
CYP1B1 source and assay evidence index
CYP1B1 primary chemistry assays and source-table locators