Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
UniProtKB reviewed entry for human CALCOCO2 (Q13137)
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Reviewed UniProt entry places CALCOCO2 in the cytoplasm, perinuclear cytoplasm, cytoskeleton, and autophagosome-related compartments
"Cytoplasm, perinuclear region"
Falcon deep research report for CALCOCO2
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Falcon research supports CALCOCO2/NDP52 as a selective autophagy receptor/adaptor in xenophagy and mitophagy, with contextual nuclear and antiviral lysosomal roles.
"strongest mechanistic consensus positions CALCOCO2/NDP52 as a selective autophagy receptor"
HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.
Towards a proteome-scale map of the human protein-protein interaction network.
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection.
Hepatitis C virus infection protein network.
Defining the membrane proteome of NK cells.
Next-generation sequencing to generate interactome datasets.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Toward an understanding of the protein interaction network of the human liver.
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion.
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Galectin-8 recruits CALCOCO2/NDP52 to damaged pathogen-containing vacuoles to activate antibacterial autophagy
"By recruiting NDP52 (also known as CALCOCO2), galectin 8 activates antibacterial autophagy."
LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.
The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium.
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NDP52 acts as a ubiquitin-dependent antibacterial autophagy adaptor
"The ubiquitinated coat is bound by ubiquitin interacting autophagy adaptor proteins (e.g., NDP52 and p62), resulting in recruitment of autophagic machinery"
A proteome-scale map of the human interactome network.
Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation.
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CALCOCO2/NDP52 promotes pathogen-containing autophagosome maturation in xenophagy
"NDP52 also promotes the maturation of autophagosomes via its interaction with LC3A, LC3B, and/or GABARAPL2 through a distinct LC3-interacting region, and with MYOSIN VI."
Widespread macromolecular interaction perturbations in human genetic disorders.
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
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CALCOCO2/NDP52 is a primary receptor for PINK1/Parkin-mediated mitophagy
"two receptors previously linked to xenophagy, NDP52 and optineurin, are the primary receptors for PINK1- and parkin-mediated mitophagy."
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Architecture of the human interactome defines protein communities and disease networks.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.
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Targeted mitochondrial CALCOCO2/NDP52 is sufficient to initiate selective autophagy through ULK1 activation
"ectopic placement of NDP52 on mitochondria or peroxisomes is sufficient to initiate selective autophagy by focally localizing and activating the ULK1 complex."
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
NDP52 Protects Against Myocardial Infarction-Provoked Cardiac Anomalies Through Promoting Autophagosome-Lysosome Fusion via Recruiting TBK1 and RAB7.
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CALCOCO2/NDP52 promotes late mitophagy flux through a fusion-linked TBK1-RAB7 pathway
"NDP52 promoted mitophagy flux through the recruitment of Ras-associated protein RAB7 (RAB7) and TANK-binding kinase 1 (TBK1)."
Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52.
Global Proximity Interactome of the Human Macroautophagy Pathway.
Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment.
Cellular localization, expression, and structure of the nuclear dot protein 52.
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CALCOCO2/NDP52 localizes mainly in the cytoplasm rather than in nuclear dots
"Our NDP52-specific sera revealed mainly cytoplasmic staining but no ND pattern, neither in untreated nor in IFN-treated cells."
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CALCOCO2/NDP52 forms homodimers
"NDP52 homodimerization but no heterodimerization with Sp100 or PML could be demonstrated."