Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
ELABELA: a hormone essential for heart development signals via the apelin receptor.
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ELA is a conserved 32-residue hormone acting through APLNR, required for zebrafish heart formation.
"Loss of Ela causes embryos to develop with a rudimentary heart or no heart at all, surprisingly phenocopying the loss of the apelin receptor (aplnr), which we show serves as Ela's cognate G protein-coupled receptor."
Elabela-apelin receptor signaling pathway is functional in mammalian systems.
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ELA signals through human APJ in mammalian cells and induces angiogenesis.
"In Chinese hamster ovarian (CHO) cells over-expressing human APJ, ELA suppresses cAMP production with EC50 of 11.1 nM, stimulates ERK1/2 phosphorylation with EC50 of 14.3 nM and weakly induces intracellular calcium mobilization."
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.
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ELA is an endogenous agonist of the human apelin receptor.
"These results show that ELA is an endogenous agonist of the human apelin receptor, exhibits a cardiovascular profile comparable to apelin"
ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
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Placenta-derived ELA prevents preeclampsia-like disease in mice.
"Elabela but not Apelin knockout pregnant mice exhibit PE-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis."
Structural insight into apelin receptor-G protein stoichiometry.
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Cryo-EM of APJ-G protein complexes with ELA bound.
"Protein preparations, in the presence of the endogenous peptide ligand ELA or a synthetic small molecule, both demonstrate these mixed stoichiometric states."
Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
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Toddler promotes mesendodermal movement during zebrafish gastrulation via APJ.
"These results indicate that Toddler is an activator of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a series of uncharacterized developmental signals."
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling.
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Apela binds APJ with Kd 0.51 nM and signals via Gi.
"Using a chimeric apela ligand, we showed direct binding of apela to APJ with high affinity (Kd = 0.51 nm) and the ability of apelin, the known peptide ligand for APJ, to compete for apela binding."
Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.
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Apela increases contractility of isolated adult rat hearts.
"Using isolated adult rat hearts, we demonstrate, that just like the fellow receptor agonist apelin, apela increases cardiac contractility and induces coronary vasodilation already in the nanomolar level."
Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
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Ela and Apj deletion impair coronary vessel development through stunted endothelial migration.
"Both heterozygous and homozygous deletions of Apj and Ela cause significant defects in coronary vessel development due to deficiencies in the migration of Apj-expressing SV-derived endothelial cells beneath the Ela-expressing epicardium."
Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling.
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Toddler regulates mesodermal cell migration downstream of Nodal.
"These results suggest that Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling and indirectly affects endodermal cell migration via Cxcr4a-signaling."
GOA annotations for APELA
Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
UniProt entry P0DMC3 (ELA_HUMAN)
Affinage mechanistic annotation for APELA (human)