Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Huntingtin facilitates dynein/dynactin-mediated vesicle transport.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Protein profile of exosomes from trabecular meshwork cells.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
PEX14 is required for microtubule-based peroxisome motility in human cells.
Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Cortical dynein is critical for proper spindle positioning in human cells.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
In vitro reconstitution of a highly processive recombinant human dynein complex.
A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.
Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle.
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
Rab46 integrates Ca(2+) and histamine signaling to regulate selective cargo release from Weibel-Palade bodies.
HENA, heterogeneous network-based data set for Alzheimer's disease.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Structure and Mechanics of Dynein Motors.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.
Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.
MAD2 converted to an inhibitory state via interaction with Mad1
MAD2 associates with the Mad1 kinetochore complex
Release of activated MAD2 from kinetochores
Phosphorylation of cohesin by PLK1 at centromeres
PP2A-B56 dephosphorylates centromeric cohesin
Transport of antigen loaded MHC II molecules to surface
ESPL1 (Separase) cleaves centromeric cohesin
Separation of sister chromatids
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Kinetochore capture of astral microtubules
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
CDC42:GTP recruits DIAPH2-2 to kinetochores
AURKB phosphorylates DIAPH2-2 at kinetochores
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
Exocytosis of azurophil granule lumen proteins
ERGIC-to-Golgi vesicles bind dynein:dynactin
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex
RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex
Dynein drives COPI-independent retrograde traffic from the Golgi to the ER
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs
HCMV Nuclear Pore Docking
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
PolyUb-Misfolded proteins bind vimentin to form aggresome
Aggresome dissociates from dynein and microtubule
EML4 recruits NUDC to mitotic spindle
Dynein motors transport misfolded proteins
Mutations in dynein link motor neuron degeneration to defects in retrograde transport.
Exome sequencing identifies a DYNC1H1 mutation in a large pedigree with dominant axonal Charcot-Marie-Tooth disease.
Mutations in DYNC1H1 cause severe intellectual disability with neuronal migration defects.
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.
Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue.
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Structure of dynein-dynactin on microtubules shows tandem adaptor binding.