Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification.
Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.
Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain.
Janus kinases in immune cell signaling.
CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Multimodal cell maps as a foundation for structural and functional genomics.
JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering.
Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.
Regulation of JAK3 expression and activation in human B cells and B cell malignancies.
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.
Jak3 activation in human lymphocyte precursor cells.
Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3
IL7:IL7R:JAK1 binds IL2RG:JAK3
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
Within the IL-2R complex JAK3 phosphorylates JAK1
Phosphorylation of IL2RB Y338 enables SHC recruitment
Recruited STAT5 is phosphorylated
SHC1 bound to IL2 receptor is phosphorylated
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
Phosphorylated SHC1 recruits GRB2:GAB2
Phosphorylated SHC recruits GRB2:SOS1
Gab2 binds the p85 subunit of Class 1A PI3 kinases
SYK is a substrate for JAK1
RAS GEFs promote RAS nucleotide exchange
p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B
JAK1 binds IL4R in IL4-bound IL4R1
p-Y705-STAT3,p-Y641-STAT6 dissociate
IL4:IL4R:JAK2 binds IL2RG:JAK3
JAK1 phosphorylates STAT3,STAT6
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
STAT3,STAT6 bind p-Y-IL4R
IL9 binds IL9R:JAK1 and IL2RG:JAK3
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated
IL15 binds IL2RB:JAK1 and IL2RG:JAK3
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2
p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3
IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3
IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B
IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3
IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5
IL21:IL21R:JAK1 binds IL2RG:JAK3
IL21 receptor JAK phosphorylation
IL21 receptor STAT phosphorylation
IL21 receptor STAT binding
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5
SHC1 mediates cytokine-induced phosphorylation of GAB2
Phosphorylated SHC1 recruits SHIP
The SHC1:SHIP1 complex is stabilized by GRB2
Phosphorylated STAT5 is released
JAK3 binds JAK3 inhibitors
Active ALK phosphorylates JAK3
PTPN6 dephosphorylates JAK3
UniProt record P52333 (JAK3)