Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.

MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.

Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.

MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription.

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription.

Human mediator subunit MED26 functions as a docking site for transcription elongation factors.

Global landscape of HIV-human protein complexes.

The little elongation complex regulates small nuclear RNA transcription.

The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.

Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL1-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons.

The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.

The super elongation complex (SEC) family in transcriptional control.

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.

AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.

A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.

A proteome-scale map of the human interactome network.

Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin.

Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.

Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.

Architecture of the human interactome defines protein communities and disease networks.

AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs.

Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization.

Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation.

Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.

Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription.

Correction to: AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

AFF4 regulates cellular adipogenic differentiation via targeting autophagy.

Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation.

AFF4 globally affects the release of paused RNA polymerase II in HEL cells.

The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release.

Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage.

Recruitment of elongation factors to form elongation complex

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex

Addition of nucleotides leads to transcript elongation

Resumption of elongation after recovery from pausing

Abortive termination of elongation after arrest

Separation of elongating transcript from template

2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing

Pol II elongation complex moves on the template as transcript elongates

TFIIS-mediated recovery of elongation from arrest

7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest

Elongating transcript encounters a lesion in the template