KCS1 (YDR017C, Q12494) notes

• Yeast IP6 kinase PMID:10574768; 5-position [UniProt:Q12494 "Reaction=1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP"].
• Also IP5 -> PP-IP4 PMID:10827188, but yeast kinase specialised for IP6 PMID:10827188.
• Kinase-dead allele abolishes PP-InsPs; leucine heptad domain needed for vacuole biogenesis [PMID:11956213 "kinase-dead" ... "two leucine heptad repeats"]; broader substrate range when overexpressed PMID:11956213.
• INO1 transcription/inositol auxotrophy PMID:23824185.
• PHO / polyP PMID:15866881.
• Cytoplasmic (GFP) [UniProt:Q12494 "SUBCELLULAR LOCATION: Cytoplasm"].

Curation decisions

• IBA 3-kinase activities (GO:0000824, GO:0008440) from PTN000963723 seeded only by ARG82 marked over-annotated (IPMK-specific; arg82 cells accumulate IP3 despite Kcs1) PMID:10683435.
• IBA lipid process GO:0046854 over-annotated (IPMK-specific).
• GO:0120517 RCA mis-mapped (IP5 -> IP6 is Ipk1): MODIFY to GO:0000827.
• GO:0010919 IMP MODIFY to GO:1900088 regulation of inositol biosynthetic process (paper is about INO1/inositol, not InsP synthesis).
• Nucleus IBA UNDECIDED (no direct yeast evidence either way).