B9D2 notes

2026-10-05 review (PAINT, affinage)

• B9 complex: PMID:32726168. The diffusion barrier is lost in knockouts (GPR161 absent from cilia), and ciliogenesis defects are mild.
• Meckel syndrome: PMID:21763481
• 18 Reactome cytosol TAS rows are kept as non-core. Fifteen come from mitotic kinetochore events: Reactome's "Kinetochore [cytosol]" complex (R-HSA-375305) lists B9D2 without a literature reference (ContentService, checked 2026-10-05). It may be worth raising with Reactome.
• Gamma-tubulin binding (mouse ISS/IEA) and nucleus are by similarity only, so they are kept as non-core. Membrane and axoneme are also non-core.
• 19 GO:0005515 rows are removed under policy. The MKS1/B9D1 partners are captured by the MKS complex rows.

2026-10-05 revision (reviewer round 1)

• Added PMID:41165761 (J Clin Invest 2026): PMID:41165761. It also shows a pre-ciliogenesis mother-centriole role (CP110 removal), so the centrosome row is now ACCEPT.
• NEW GO:0030674 protein-macromolecule adaptor activity (IDA, PMID:32726168). B9D2 is the middle subunit of MKS1-B9D2-B9D1. MKS1 and B9D1 carry only protein binding in GOA.
• Corrected the GO:0005515 count to 19; the first history record said 20.